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Comment
. 2018 Apr 4;38(14):3388-3390.
doi: 10.1523/JNEUROSCI.0028-18.2018.

c-Jun in Schwann Cells: Stay Away from Extremes

Gianluca Figlia  1
Affiliations
Comment

c-Jun in Schwann Cells: Stay Away from Extremes

Gianluca Figlia. J Neurosci. .
No abstract available

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Conflict of interest statement

The author declares no competing financial interests.

Figures

Figure 1.
Figure 1.
Schematic representation of the consequences of low or high c-Jun levels on nerve regeneration. Deletion of c-Jun in Schwann cells leads to slower myelin clearance, slower axon regrowth, and greater loss of neurons after nerve injury. Conversely, overexpression of c-Jun in Schwann cells results in faster myelin clearance but impairs the subsequent remyelination program.
See this image and copyright information in PMC

Comment on

References

    1. Arthur-Farraj PJ, Latouche M, Wilton DK, Quintes S, Chabrol E, Banerjee A, Woodhoo A, Jenkins B, Rahman M, Turmaine M, Wicher GK, Mitter R, Greensmith L, Behrens A, Raivich G, Mirsky R, Jessen KR (2012) c-Jun reprograms Schwann cells of injured nerves to generate a repair cell essential for regeneration. Neuron 75:633–647. 10.1016/j.neuron.2012.06.021 - DOI - PMC - PubMed
    1. Arthur-Farraj PJ, Morgan CC, Adamowicz M, Gomez-Sanchez JA, Fazal SV, Beucher A, Razzaghi B, Mirsky R, Jessen KR, Aitman TJ (2017) Changes in the coding and non-coding transcriptome and DNA methylome that define the Schwann cell repair phenotype after nerve injury. Cell Rep 20:2719–2734. 10.1016/j.celrep.2017.08.064 - DOI - PMC - PubMed
    1. Brosius Lutz A, Barres BA (2014) Contrasting the glial response to axon injury in the central and peripheral nervous systems. Dev Cell 28:7–17. 10.1016/j.devcel.2013.12.002 - DOI - PubMed
    1. Brosius Lutz A, Chung WS, Sloan SA, Carson GA, Zhou L, Lovelett E, Posada S, Zuchero JB, Barres BA (2017) Schwann cells use TAM receptor-mediated phagocytosis in addition to autophagy to clear myelin in a mouse model of nerve injury. Proc Natl Acad Sci U S A 114:E8072–E8080. 10.1073/pnas.1710566114 - DOI - PMC - PubMed
    1. Decker L, Desmarquet-Trin-Dinh C, Taillebourg E, Ghislain J, Vallat JM, Charnay P (2006) Peripheral myelin maintenance is a dynamic process requiring constant Krox20 expression. J Neurosci 26:9771–9779. 10.1523/JNEUROSCI.0716-06.2006 - DOI - PMC - PubMed

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