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. 2018 Apr 4;8(1):5595.
doi: 10.1038/s41598-018-23127-6.

Results of the radiation dose of head, body and tail of hippocampus in nasopharyngeal carcinoma patients treated with intensity modulated radiotherapy

Sun Zong-Wen  1 , Shi Lei  2 , Li Qinglin  3 , Kong Yue  4 , Du Feng-Lei  4 , Xie Tie-Ming  2 , Hua Yong-Hong  4 , Hu Qiao-Ying  4 , Chen Xiao-Zhong  4 , Chen Yuan-Yuan  5 , Chen Ming  4
Affiliations

Results of the radiation dose of head, body and tail of hippocampus in nasopharyngeal carcinoma patients treated with intensity modulated radiotherapy

Sun Zong-Wen et al. Sci Rep. .

Abstract

This study is to analyze the radiation dose of head, body and tail of hippocampus (HC) of nasopharyngeal carcinoma (NPC) patients treated with intensity modulated radiotherapy (IMRT). Evaluate cognitive function of patients with Wechsler adult intelligence scale-Chinese revised (WAIS-CR). HC were segmented into HC head (HH), HC body (HB) and HC tail (HT) and the indexes were then analyzed. WAIS-CR was tested before and 3months after radiotherapy. The mean radiation dose of left and right HC was (1147 ± 976)cGy, (1011 ± 602)cGy respectively. The radiation dose and the volume exposed in different dose of HH, HB and HT decreased in turn. For 5 patients, before and after radiotherapy, the regular-order score was 8.60 ± 1.34, 8.0 ± 1.00 (P = 0.43), while the reverse-order score was 5.80 ± 0.84, 5.20 ± 0.84 (P = 0.07). The radiation dose of HH, HB and HT was different, and the radiation dose of HH was the highest, which should be emphasized especially.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
The segmentation of HC.
Figure 2
Figure 2
The segmentation of HC and dose distribution. (a) The segmentation on two dimension; (b) The isodose curve on two dimension; (c) The segmentation on three dimension; (d) The DVH curve.
Figure 3
Figure 3
Diagram of the radiation dose of right HT was higher than HB. (a) The DVH curve; (b–f) the dose coverage of right HB and HT.
See this image and copyright information in PMC

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