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. 2018 Nov;40(1):252-258.
doi: 10.1080/0886022X.2018.1456455.

The role of mitofilin in left ventricular hypertrophy in hemodialysis patients

Qi-Shun Wu  1 , Qing He  2 , Jian-Qiang He  1 , Jun Chao  1 , Wen-Yan Wang  1 , Yan Zhou  1 , Ji-Zhuang Lou  2 , Wei Kong  3 , Jun-Feng Chen  3
Affiliations

The role of mitofilin in left ventricular hypertrophy in hemodialysis patients

Qi-Shun Wu et al. Ren Fail. 2018 Nov.

Abstract

Left ventricular hypertrophy (LVH) is a common abnormality in hemodialysis (HD) patients. Mitochondrial dysfunction contributes to the progression of LVH. As an inner mitochondrial membrane structural protein, mitofilin plays a key role in maintaining mitochondrial structure and function. The aim of this study was to investigate the relationship between mitofilin and LVH in HD patients. A total of 98 HD patients and 32 healthy controls were included in the study. Serum N-terminal proBNP (NT-proBNP), endothelin-1 (ET-1), and atrial natriuretic peptide (ANP) were examined. The protein level of mitofilin and the mitochondrial DNA (mtDNA) copy number were estimated in peripheral blood mononuclear cells (PBMCs). The left ventricle mass index (LVMI) was evaluated in all participants, and the interaction between these variables and the LVMI was assessed. The LVMI was positively correlated with the NT-proBNP, ET-1, and ANP levels, and it was negatively correlated with mtDNA copy number and mitofilin levels. Multiple regression analysis showed that the NT-proBNP, ET-1, and ANP levels as well as mitofilin levels and mtDNA copy number were associated with the LVMI. Although further research of these associations is needed, this result suggests that LVH may affect the levels of mitofilin in HD patients.

Keywords: hemodialysis; left ventricular hypertrophy; mitochondria; mitofilin; peripheral blood mononuclear cells.

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Figures

Figure 1.
Figure 1.
Cardiac marker levels in the HD patients and control group. NT-proBNP: N-terminal proBNP; ET-1: endothelin-1; ANP: atrial natriuretic peptide; LVH: left ventricular hypertrophy. ##p < .01 vs. control group; **p < .01 vs. patients without LVH.
Figure 2.
Figure 2.
mtDNA copy numbers and mitofilin protein levels in PBMCs from the control and HD groups. HD: hemodialysis; LVH: left ventricular hypertrophy; mtDNA: mitochondrial DNA; PBMCs: peripheral blood mononuclear cells; ##p < .01 vs. control group; *p < .05 vs. patients without LVH; **p < .01 vs. patients without LVH.
See this image and copyright information in PMC

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