doi: 10.1038/330722a0.
T-cell receptor delta gene rearrangements in early thymocytes
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- PMID: 2961997
- DOI: 10.1038/330722a0
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T-cell receptor delta gene rearrangements in early thymocytes
Nature.
1987 Dec.
Abstract
The T-cell receptor delta-chain variable region can be assembled from as many as four distinct gene segments, V, D1, D2 and J, more than any other antigen-receptor gene. In fetal thymocytes V----D joinings are as common as D----J or VDJ rearrangements and one V gene segment predominates. Analysis of rearrangements at TCR gamma and delta loci during fetal ontogeny suggests abrupt changes and possible coordinate control in the rearrangement and expression of these loci.
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