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Review
. 2018 Aug 23;61(16):7004-7031.
doi: 10.1021/acs.jmedchem.8b00260. Epub 2018 Apr 19.

Synthetic Approaches to New Drugs Approved During 2016

Andrew C Flick  1 , Hong X Ding  2 , Carolyn A Leverett  1 , Sarah J Fink  3 , Christopher J O'Donnell  1
Affiliations
Review

Synthetic Approaches to New Drugs Approved During 2016

Andrew C Flick et al. J Med Chem. .

Abstract

New drugs introduced to the market every year represent privileged structures for particular biological targets. These new chemical entities provide insight into molecular recognition while serving as leads for designing future new drugs. This annual review describes the most likely process-scale synthetic approaches to 19 new chemical entities that were approved for the first time in 2016.

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MeSH terms

Substances