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Review
. 2018 Apr 5;14(4):e1006904.
doi: 10.1371/journal.ppat.1006904. eCollection 2018 Apr.

Polyvalent vaccines: High-maintenance heroes

Affiliations
Review

Polyvalent vaccines: High-maintenance heroes

Barbara Schlingmann et al. PLoS Pathog. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

I have read the journal’s policy and have the following conflict. MLM is employed by Meissa Vaccines, Inc.

Figures

Fig 1
Fig 1. Current challenges and development of polyvalent vaccines.
(A) Current potential challenges to development of polyvalent vaccine preparations. (B) Development and licensing of polyvalent vaccines in the United States. Combination vaccines are not reviewed here. Different colors indicate vaccines against the same pathogen. Blue, Streptococcus pneumoniae (polysaccharide vaccine and conjugate vaccine); red, poliovirus (inactivated vaccine and oral, live-attenuated vaccine); purple, Neissaeria meningitides (meningococcal vaccine: polysaccharide and conjugate vaccine); yellow, rotavirus (live attenuated); green, HPV, VLP; gray, adenovirus; white, influenza (inactivated and live-attenuated vaccines). Not all influenza vaccines are included. HPV, human papillomavirus; QC, quality control; VLP, viruslike particle.

References

    1. Andre FE, Booy R, Bock HL, Clemens J, Datta SK, John TJ, et al. Vaccination greatly reduces disease, disability, death and inequity worldwide. Bulletin of the World Health Organization. 2008;86(2):140–6. Epub 2008/02/26. doi: 10.2471/BLT.07.040089 - DOI - PMC - PubMed
    1. CDC. Epidemiology and Prevention of Vaccine-Preventable Diseases. 13th ed Hamborsky J, K A, Wolfe S, editor. Washington D.C.: Public Health Foundation; 2015.
    1. Smith J, Lipsitch M, Almond JW. Vaccine production, distribution, access and uptake. Lancet. 2011;378(9789):428–38. doi: 10.1016/S0140-6736(11)60478-9 - DOI - PMC - PubMed
    1. FDA. Guidance for industry for the evaluation of combination vaccines for preventable diseases: production, testing and clinical studies 1997. http://www.fda.gov/downloads/BiologicsBloodVaccines/GuidanceComplianceRe....
    1. Guess HA. Combination vaccines: issues in evaluation of effectiveness and safety. Epidemiologic reviews. 1999;21(1):89–95. Epub 1999/10/16. . - PubMed

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