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Review
. 2018 Apr:51:162-169.
doi: 10.1016/j.coi.2018.03.017. Epub 2018 Apr 2.

Transcriptional programming of tissue-resident memory CD8+ T cells

J Justin Milner  1 , Ananda W Goldrath  2
Affiliations
Review

Transcriptional programming of tissue-resident memory CD8+ T cells

J Justin Milner et al. Curr Opin Immunol. 2018 Apr.

Abstract

Tissue-resident memory CD8+ T cells (TRM) are localized in non-lymphoid tissues throughout the body where they mediate long-lived protective immunity at common sites of pathogen exposure. As the signals controlling TRM differentiation are uncovered, it is becoming apparent that the dynamic activities of numerous transcription factors are intricately involved in TRM formation. Here, we highlight known transcriptional regulators of TRM differentiation and discuss how understanding the transcriptional programming of CD8+ T cell residency in non-lymphoid tissues can be leveraged to prevent or treat disease.

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Figures

Figure 1
Figure 1. TRM exhibit a hybrid effector/memory TF-driven differentiation program
A, Key TFs with known functions in controlling TE vs. MP differentiation are highlighted. B, TFs critical to TRM differentiation are included (inside the circle) or that suppress TRM development relative to circulating memory (outside the circle). Additionally, TFs that are predicted to be required for TRM differentiation based on gene expression [49] (inside the circle) or predicted to suppress TRM differentiation (outside the circle) are included. TFs with validated roles are bolded whereas predicted regulators are not.
Figure 2
Figure 2. TF regulation of TRM differentiation
TFs with established roles in promoting TRM are highlighted in green, those repressing TRM are highlighted in red, and putative regulators are gray. dLN; draining lymph node.
See this image and copyright information in PMC

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