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. 2018 May 17;51(5):1800171.
doi: 10.1183/13993003.00171-2018. Print 2018 May.

Gadofosveset-enhanced lung magnetic resonance imaging to detect ongoing vascular leak in pulmonary fibrosis

Sydney B Montesi  1 , Rohan Rao  1 , Lloyd L Liang  1 , Hannah E Goulart  1 , Amita Sharma  2 , Subba R Digumarthy  2 , Barry S Shea  3 , Ravi T Seethamraju  4   5 , Peter Caravan  2   5   6 , Andrew M Tager  1
Affiliations

Gadofosveset-enhanced lung magnetic resonance imaging to detect ongoing vascular leak in pulmonary fibrosis

Sydney B Montesi et al. Eur Respir J. .

Abstract

Vascular leak is increased diffusely in the lungs in pulmonary fibrosis and is not limited to radiographic areas of disease involvement.

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Conflict of interest statement

Conflict of interest: S.B. Montesi reports receiving grants from the Parker B. Francis Foundation, the National Institutes of Health, Harvard Catalyst and the Chest Foundation, during the conduct of the study. Conflict of interest: B.S. Shea reports receiving grants from the National Institutes of Health/NHLBI during the conduct of the study; and consulting fees from Boehringer Ingelheim and Roche-Genentech, and grants from Biogen, outside the submitted work. Conflict of interest: R.T. Seethamraju is an employee of Siemens Healthineers, the manufacturer of MRI machines on which this study was performed. In addition, he has two patents, “Free-breathing Radial-MR Angiography with No Contrast (FRANC)” and “Non-contrast Breath Held MR Perfusion of the Lungs from Time Series Analysis”, pending to Siemens and Brigham and Women's Hospital. Conflict of interest: P. Caravan reports receiving grants from the National Institutes of Health during the conduct of the study; and personal fees and nonfinancial support from Collagen Medical LLC, nonfinancial support from Factor 1A LLC and Reveal Pharmaceuticals, grants from Pfizer and Pliant, and personal fees from Bayer and Guerbet, outside the submitted work.

Figures

Figure 1.
Figure 1.. Coronal Subtraction Images with Color Overlay.
Subtraction of baseline pre-gadofosveset image from 15 minute post-gadofosveset image (color) super-imposed on baseline image. (A) Healthy Control. (B) Subject with IPF. (C) CT scan of the same subject with IPF. In panel A, signal enhancement is isolated to areas of known blood vessels with the majority of the lung unenhanced. In panel B, regions of signal enhancement extend well beyond major vessels and into the lung parenchyma consistent with increased albumin extravasation. When comparing panel B to panel C, regions of increased signal intensity occur in areas of radiographically normal lung in addition to areas with known fibrosis.
See this image and copyright information in PMC

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