Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Mar 22:9:259.
doi: 10.3389/fphys.2018.00259. eCollection 2018.

Functional Changes Induced by Orexin A and Adiponectin on the Sympathetic/Parasympathetic Balance

Antonietta Messina  1 , Marcellino Monda  1 , Anna Valenzano  2 , Giovanni Messina  2 , Ines Villano  1 , Fiorenzo Moscatelli  2 , Giuseppe Cibelli  2 , Gabriella Marsala  3 , Rita Polito  4 , Maria Ruberto  5 , Marco Carotenuto  6 , Vincenzo Monda  1 , Andrea Viggiano  7 , Aurora Daniele  4 , Ersilia Nigro  4
Affiliations

Functional Changes Induced by Orexin A and Adiponectin on the Sympathetic/Parasympathetic Balance

Antonietta Messina et al. Front Physiol. .

Abstract

Obesity and lifestyle-related diseases are major problems faced by people in developed nations. Although exercise training prevents the progression of diabetes and obesity, the motivation for exercise is generally low in obese animals and humans. The autonomic nervous system (SNA) plays a crucial role in the regulation of eating behavior. Moreover, the SNA is involved in the body temperature regulation that is strictly related to body weight control, in accordance with the "thermoregulatory hypothesis" of food intake. Some neuronal peptides and hormones, like orexins and adiponectin, are also involved in the regulation of locomotion activity as well as food intake and metabolic rate. Furthermore, adiponectin as well as orexin A are involved in the control of body temperature, food intake and therefore in obesity-related diseases. The aim of this study was to investigate the changes in body temperature (Tc), and heart rate (HR) after an intracerebroventricular (ICV) injection of orexin A and adiponectin in animal model. The results of this study show that the orexin A levels are likely involved in the increase of Tc and HR. It is also clear that there is not a correlation between these parameters and adiponectin levels. Further studies are needed to assess adiponectin actions and outcome in the central nervous system in terms of energy expenditure, body temperature, heart rate and physical activity performance regulation.

Keywords: ICV-injection; adiponectin; body temperature; heart rate; orexin A.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Means ± SD of values of Tc. Intracerebroventricular (icv) injection of adiponectin (0.1 μg/g), or saline or orexin A (1.5 nmol) was made at time 0 and they were monitored each 30 for 180 min. post-injections. ***p < 0.001; *p < 0.05.
Figure 2
Figure 2
Means ± SD of values of HR. Intracerebroventricular (icv) injection of adiponectin (0.1 μg/g), or saline or orexin A (1.5 nmol) was made at time 0 and they were monitored each 30 for 180 min. post-injections. ***p < 0.001; *p < 0.05.
See this image and copyright information in PMC

References

    1. Accetta R., Damiano S., Morano A., Mondola P., Paternò R., Avvedimento E. V., et al. (2016). Oxygen species derived from NOX3 and NOX5 drive differentiation of human oligodendrocytes. Front. Cell. Neurosci. 10:146. 10.3389/fncel.2016.00146 - DOI - PMC - PubMed
    1. Avola R., Di Tullio M. A., Fisichella A., Tayebati S. K., Tomassoni D. (2004). Glial fibrillary acidic protein and vimentin expression is regulated by glucocorticoids and neurotrophic factors in primary rat astroglial cultures. Clin. Exp. Hypertens. 26, 323–333. 10.1081/CEH-120034137 - DOI - PubMed
    1. Bafunno V., Bury L., Tiscia G. L., Fierro T., Favuzzi G., Caliandro R., et al. (2014). A novel congenital dysprothrombinemia leading to defective prothrombin maturation. Thromb. Res. 134, 1135–1141. 10.1016/j.thromres.2014.08.028 - DOI - PubMed
    1. Bayer L., Eggermann E., Serafin M., Saint-Mleux B., Machard D., Jones B., et al. (2001). Orexins (hypocretins) directly excite tuberomammillary neurons. Eur. J. Neurosci. 14, 1571–1575. 10.1046/j.0953-816x.2001.01777.x - DOI - PubMed
    1. Bertozzi G., Sessa F., Albano G. D., Sani G., Maglietta F., Roshan M. H. K., et al. (2017). The role of anabolic androgenic steroids in disruption of the physiological function in discrete areas of the central nervous system. Mol. Neurobiol. [Epub ahead of print]. 10.1007/s12035-017-0774-1 - DOI - PMC - PubMed