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. 2018 Apr;32(2):169-173.
doi: 10.1007/s10557-018-6787-9.

Effect of Antazoline on Electrophysiological Properties of Atrial Muscle and Conduction System of the Heart

Bartłomiej Jacek Bińkowski  1 , Marcin Makowski  2 , Paweł Kubiński  2 , Andrzej Lubiński  2
Affiliations

Effect of Antazoline on Electrophysiological Properties of Atrial Muscle and Conduction System of the Heart

Bartłomiej Jacek Bińkowski et al. Cardiovasc Drugs Ther. 2018 Apr.

Abstract

Purpose: Antazoline is a first-generation antihistaminic agent with additional anticholinergic properties and antiarrhythmic potential. Recent data shows its high effectiveness in sinus rhythm restoration among patients with paroxysmal atrial fibrillation. The effect of antazoline on electrophysiological parameters of the heart in vivo has not yet been examined. The aim of this study was to evaluate changes in electrophysiological parameters of the heart muscle and conduction system as a response to increasing doses of antazoline.

Methods: After successful ablation of supraventricular arrhythmias, the electrophysiological parameters: sinus rhythm cycle length (SRCL), AH, HV, QRS, QT, QTc intervals, Wenckebach point (WP), sinus node recovery period (SNRT), intra- (hRA-CSos) and interatrial conduction time (hRA-CSd), right and left atrium refractory period (RA-; LA-ERP), and atrioventricular node refractory period (AVN-ERP) were assessed initially and after 100, 200, and 300 mg of antazoline given intravenously.

Results: Fifteen patients (8 males, 19-72 years old) undergoing EPS and RF ablation were enrolled. After 100 mg bolus, a significant reduction in SRCL was noticed. After antazoline administration, significant prolongation of HV, QRS, QTc, hRA-CSos, hRA-CSd intervals, RA- and LA-ERP and reduction of SRCL were observed. After a total dose of 300 mg, QT interval prolonged significantly. Increasing the dose of antazoline had no impact on AH, Wenckebach point, AVN-ERP, and SNRT.

Conclusion: Antazoline has an effect on electrophysiological parameters of the atrial muscle and has rapid onset of action. No negative effect on sinus node function and atrioventricular conduction in a unique property among antiarrhythmic drugs.

Keywords: Antazoline; Antiarrhythmic drug; Electrophysiological study.

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Conflict of interest statement

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Figures

Fig. 1
Fig. 1
Effect of antazoline on electrophysiological properties of atrial muscle and conduction system of the heart. SRCL, sinus rhythm cycle length; hRA-CSos, intraatrial conduction time; hRA-CSd interatrial conducion time; RA-ERP right atrium refractory period; LA-ERP, left atrium refractory; AVN-ERP, atrioventricular node refractory period; WP, Wenckebach point; SNRT, sinus node recovery period; T0 initial value, T100 after 100, T200 after 200, T300 after 300 mg of antazoline. *p < 0.05, **p < 0.01, ***p < 0.001
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References

    1. Heinberg CJ. A new synthetic anti-histaminic substance, antistine. Eye Ear Nose Throat Mon. 1947;26:639–641. - PubMed
    1. McKechnie JK. The cardiac action of the antihistamine compounds. S Afr Med J. 1952;26:609–613. - PubMed
    1. Angelakos ET. Influence of pharmacological agents on spontaneous and surgically induced hypothermic ventricular fibrillation. Ann N Y Acad Sci. 1959;80:351–364. doi: 10.1111/j.1749-6632.1959.tb49216.x. - DOI - PubMed
    1. Angelakos ET, Hegnauer AH. Pharmacological agents for the control of spontaneous ventricular fibrillation under progressive hypothermia. J Pharmacol Exp Ther. 1959;127:137–145. - PubMed
    1. Kline SR, Dreifus LS, Watanabe Y, et al. Evaluation of the antiarrhythmic properties of antazoline. A preliminary study. Am J Cardiol. 1962;9:564–567. doi: 10.1016/0002-9149(62)90075-9. - DOI - PubMed

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