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. 2018 May;6(3):401-408.
doi: 10.1002/mgg3.368. Epub 2018 Apr 6.

A genetic variant in IL-15Rα correlates with physical activity among European-American adults

Michael Bruneau Jr  1 , Sean Walsh  2 , Eric Selinsky  3 , Garrett Ash  4 , Theodore J Angelopoulos  5 , Priscilla Clarkson  6 , Paul Gordon  7 , Niall Moyna  8 , Paul Visich  9 , Robert Zoeller  10 , Paul Thompson  11 , Heather Gordish-Dressman  12 , Eric Hoffman  13 , Joseph Devaney  12 , Linda S Pescatello  3   14
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A genetic variant in IL-15Rα correlates with physical activity among European-American adults

Michael Bruneau Jr et al. Mol Genet Genomic Med. 2018 May.

Abstract

Background: Interleukin-15 (IL-15) is a myokine associated with muscle strength, possibly by attenuating protein breakdown. A variant in the alpha-receptor (IL-15Rα 1775 A>C, rs2228059) partially modulates the muscle strength and size response to resistance training. We examined if this polymorphism associated with habitual physical activity among European-American adults.

Methods: Men (n = 240, 23.7 ± 0.3 year, body mass index [BMI] 25.3 ± 0.3 kg/m2 ) and women (n = 292, 23.2 ± 0.3 year, 24.0 ± 0.3 kg/m2 ) were genotyped. Physical activity phenotypes were derived from the Paffenbarger Physical Activity Questionnaire. Analysis of covariance (ancova) tested log-transformed differences between the IL-15Rα genotype and physical activity phenotypes by gender with age and BMI as covariates.

Results: Men with the IL-15Rα 1775AA genotype spent more time in light intensity physical activity (39.4 ± 2.4 hr/week) than men with the CC genotype (28.6 ± 2.3 hr/week, (p = .009).

Conclusion: Further research is needed to confirm our finding and determine the possible mechanisms by which the IL-15Rα variant modulates light intensity physical activity.

Keywords: cytokine; exercise; polymorphisms.

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Figures

Figure 1
Figure 1
Time spent (X ± SEM) sitting (a) and in light (b), moderate (c), and vigorous (d) physical activity (hr) by IL‐15Rα 1775 A>C (rs2228059) genotype and sex
See this image and copyright information in PMC

References

    1. Ainsworth, B. E. , Leon, A. S. , Richardson, M. T. , Jacobs, D. R. , & Paffenbarger, R. S. Jr. (1993). Accuracy of the college alumnus physical activity questionnaire. Journal of Clinical Epidemiology, 46, 1403–1411. https://doi.org/10.1016/0895-4356(93)90140-V - DOI - PubMed
    1. Ajuwon, K. M. , & Spurlock, M. E. (2004). Direct regulation of lipolysis by interleukin‐15 in primary pig adipocytes. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 287, R608–R611. https://doi.org/10.1152/ajpregu.00192.2004 - DOI - PubMed
    1. Almendro, V. , Fuster, G. , Ametller, E. , Costelli, P. , Pilla, F. , Busquets, S. , … Lopez‐Soriano, F. J. (2009). Interleukin‐15 increases calcineurin expression in 3T3‐L1 cells: Possible involvement on in vivo adipocyte differentiation. International Journal of Molecular Medicine, 24, 453–458. - PubMed
    1. American College of Sports . (2017). ACSM's guidelines for exercise testing and prescription Philadelphia Lippincott. Philadelphia, PA: Williams & Wilkins.
    1. Arnett, D. K. , Devereux, R. B. , Rao, D. C. , Li, N. , Tang, W. , Kraemer, R. , … Broeckel, U. (2009). Novel genetic variants contributing to left ventricular hypertrophy: The HyperGEN study. Journal of Hypertension, 27, 1585–1593. https://doi.org/10.1097/HJH.0b013e32832be612 - DOI - PMC - PubMed

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