To Be Young at Heart

Patrick C H Hsieh¹, Timothy J Kamp²

Affiliations

¹ Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA; Stem Cell and Regenerative Medicine Center, University of Wisconsin-Madison, Madison, WI, USA. Electronic address: phsieh@ibms.sinica.edu.tw.
² Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA; Stem Cell and Regenerative Medicine Center, University of Wisconsin-Madison, Madison, WI, USA; Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI, USA. Electronic address: tjk@medicine.wisc.edu.

PMID: 29625063
DOI: 10.1016/j.stem.2018.03.003

Free article

Comment

To Be Young at Heart

Patrick C H Hsieh et al. Cell Stem Cell. 2018.

Free article

. 2018 Apr 5;22(4):475-476.

doi: 10.1016/j.stem.2018.03.003.

Authors

Patrick C H Hsieh¹, Timothy J Kamp²

Affiliations

¹ Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA; Stem Cell and Regenerative Medicine Center, University of Wisconsin-Madison, Madison, WI, USA. Electronic address: phsieh@ibms.sinica.edu.tw.
² Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA; Stem Cell and Regenerative Medicine Center, University of Wisconsin-Madison, Madison, WI, USA; Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI, USA. Electronic address: tjk@medicine.wisc.edu.

PMID: 29625063
DOI: 10.1016/j.stem.2018.03.003

Abstract

Recently in Cell, Mohamed et al. (2018) report a cell-cycle regulator gene cocktail identified from young cardiomyocytes that enables mouse, rat, and human cardiomyocyte proliferation and promotes heart regeneration after infarction, defying the non-dividing nature of adult mammalian cardiomyocytes and implying a new way to treat or prevent heart failure.

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Regulation of Cell Cycle to Stimulate Adult Cardiomyocyte Proliferation and Cardiac Regeneration.
Mohamed TMA, Ang YS, Radzinsky E, Zhou P, Huang Y, Elfenbein A, Foley A, Magnitsky S, Srivastava D. Mohamed TMA, et al. Cell. 2018 Mar 22;173(1):104-116.e12. doi: 10.1016/j.cell.2018.02.014. Epub 2018 Mar 1. Cell. 2018. PMID: 29502971 Free PMC article.

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To Be Young at Heart

Affiliations

To Be Young at Heart

Authors

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Medical