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. 2018 Jul:61:183-184.
doi: 10.1016/j.meegid.2018.03.028. Epub 2018 Apr 4.

Predicting the receptor-binding domain usage of the coronavirus based on kmer frequency on spike protein

Zhaozhong Zhu  1 , Zheng Zhang  1 , Wenjun Chen  1 , Zena Cai  1 , Xingyi Ge  1 , Haizhen Zhu  2 , Taijiao Jiang  3 , Wenjie Tan  4 , Yousong Peng  5
Affiliations

Predicting the receptor-binding domain usage of the coronavirus based on kmer frequency on spike protein

Zhaozhong Zhu et al. Infect Genet Evol. 2018 Jul.
No abstract available

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Figures

Fig. 1
Fig. 1
Predicting the RBD usage of the coronavirus based on the number of “FS” in the protein sequence of the spike protein S1 subunit. (A) The distribution of the number of “FS” in S1 and the predictive accuracy based on the number of “FS” in 12 coronavirus species. The coronavirus species using NTD and CTD were colored in blue and red, respectively. The genus each virus belongs to was labeled in the top right of the virus name. (B) and (C) refer to the 3D structure of S1 subunit for MHV and HCoV-NL63, respectively. The receptor-binding interface was inferred manually from the spike-receptor complex (PDB id: 3r4d for MHV and 3kbh for HCoV-NL63). NTD and CTD were colored in cyan and yellow respectively. The “FS”s were colored in blue. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
See this image and copyright information in PMC

References

    1. Li F. Receptor recognition mechanisms of coronaviruses: a decade of structural studies. J. Virol. 2015;89:1954–1964. - PMC - PubMed
    1. Li F. Structure, function, and evolution of coronavirus spike proteins. Ann. Rev. Virol. 2016;3:237–261. - PMC - PubMed
    1. Lu G.W., Wang Q.H., Gao G.F. Bat-to-human: spike features determining 'host jump' of coronaviruses SARS-CoV, MERS-CoV, and beyond. Trends Microbiol. 2015;23:468–478. - PMC - PubMed
    1. Peck K.M., Burch C.L., Heise M.T., Baric R.S. Coronavirus host range expansion and Middle East respiratory syndrome coronavirus emergence: biochemical mechanisms and evolutionary perspectives. Ann. Rev. Virol. 2015;2(2):95–117. - PubMed
    1. Peng G.Q., Sun D.W., Rajashankar K.R., Qian Z.H., Holmes K.V., Li F. Crystal structure of mouse coronavirus receptor-binding domain complexed with its murine receptor. Proc. Natl. Acad. Sci. U. S. A. 2011;108:10696–10701. - PMC - PubMed

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