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Meta-Analysis
. 2018 Sep:119:5-16.
doi: 10.1016/j.urology.2018.03.028. Epub 2018 Apr 4.

What Is the Role of α-Blockers for Medical Expulsive Therapy? Results From a Meta-analysis of 60 Randomized Trials and Over 9500 Patients

Omar M Aboumarzouk  1 , Patrick Jones  2 , Tarik Amer  3 , Dimitris Kotsiris  4 , Esteban Emiliani  4 , Bhaskar Somani  4 , Panagiotis Kallidonis  4 , Thomas Tailly  4 , Gohkan Atis  4 , Francesco Greco  4 , Stephan Hruby  4 , Mario Alvarez  4 , Khalid Al-Rumaihi  5 , Ahmad Shamsodini  5 , Abdulla Al-Ansari  4 , Ahmed Shokeir  6
Affiliations
Meta-Analysis

What Is the Role of α-Blockers for Medical Expulsive Therapy? Results From a Meta-analysis of 60 Randomized Trials and Over 9500 Patients

Omar M Aboumarzouk et al. Urology. 2018 Sep.

Abstract

Use of α-blockers for medical expulsive therapy (MET) has been the subject of huge debate in urology. Moreover, there have been a number of randomized controlled trials with differing results. We conducted a systematic review and meta-analysis of randomized controlled trials investigating the efficacy of α-blockers for MET. This review confirms there is a role for α-blockers in MET for ureteric stones specifically in stones >5 mm and distal ureteric stones, which is associated with improved stone expulsion. However, there is a slight increase in risk of nonsignificant side effects.

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