Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2018 Apr 7:2018:bcr2018224346.
doi: 10.1136/bcr-2018-224346.

Pemphigoid gestationis successfully treated with intravenous immunoglobulin

Filipa Tavares Almeida  1 , Rita Sarabando  2 , Joana Pardal  3 , Celeste Brito  1
Affiliations
Case Reports

Pemphigoid gestationis successfully treated with intravenous immunoglobulin

Filipa Tavares Almeida et al. BMJ Case Rep. .

Abstract

Pemphigoid gestationis (PG), also known as herpes gestationis, is a rare autoimmune blistering disease specific to pregnancy, which usually presents in the second or third trimesters and, in 15%-25% of cases, during the immediate postpartum period.1Although the ethiopathogeny of PG is not fully clarified, most patients develop antibodies against a 180 kDa transmembrane hemidesmosomal protein (BP180; BPAG2; collagen XVII).2 PG has a strong association with human leucocyte antigens DR3 and DR4.3We report a case of a 29-year-old female patient with PG successfully treated with intravenous immunoglobulin.

Keywords: dermatology; obstetrics and gynaecology; obstetrics, gynaecology and fertility.

PubMed Disclaimer

Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Erythemato-oedematous plaques located on the abdomen and thighs.
Figure 2
Figure 2
Erythemato-oedematous plaques centred by vesicles and tense blisters (left thigh).
Figure 3
Figure 3
Skin with a dermo-epidermal blister containing polymorphonuclear neutrophils (H&E 100×). Inset: perivascular inflammatory infiltrate with eosinophils in the dermis (H&E 400×).
Figure 4
Figure 4
Linear deposition of C3 along the dermo-epidermal junction (direct immunofluorescence).
See this image and copyright information in PMC

References

    1. Hallaji Z, Mortazavi H, Ashtari S, et al. . Pemphigoid gestationis: clinical and histologic features of twenty-three patients. Int J Womens Dermatol 2017;3:86–90. 10.1016/j.ijwd.2016.11.004 - DOI - PMC - PubMed
    1. Ingen-Housz-Oro S. [Pemphigoid gestationis: a review]. Ann Dermatol Venereol 2011;138:209–13. 10.1016/j.annder.2011.01.011 - DOI - PubMed
    1. Al-Fouzan AW, Galadari I, Oumeish I, et al. . Herpes gestationis (Pemphigoid gestationis). Clin Dermatol 2006;24:109–12. 10.1016/j.clindermatol.2005.10.011 - DOI - PubMed
    1. Semkova K, Black M. Pemphigoid gestationis: current insights into pathogenesis and treatment. Eur J Obstet Gynecol Reprod Biol 2009;145:138–44. 10.1016/j.ejogrb.2009.05.012 - DOI - PubMed
    1. Sadik CD, Lima AL, Zillikens D. Pemphigoid gestationis: toward a better understanding of the etiopathogenesis. Clin Dermatol 2016;34:378–82. 10.1016/j.clindermatol.2016.02.010 - DOI - PubMed

Publication types

Substances