Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2018 Jan-Mar;9(1):47-49.
doi: 10.4103/jmh.JMH_59_17.

Myofibroblastoma of the Breast: A Rare Cause of Breast Lump in a Postmenopausal Woman

Yasmeen Khatib  1 , Vinita Pandey  1 , Archana L Khade  1 , Rahul Pandey  2
Affiliations
Case Reports

Myofibroblastoma of the Breast: A Rare Cause of Breast Lump in a Postmenopausal Woman

Yasmeen Khatib et al. J Midlife Health. 2018 Jan-Mar.

Abstract

A breast mass in a postmenopausal age woman is treated with a high index of clinical suspicion for malignancy. Myofibroblastoma (MFB) of the breast is a very rare benign stromal tumor, predominantly occurring in menopausal women and older men. Owing to its rarity, nonspecific radiology, cytomorphology, and many variants, it can be confused with other malignant and benign breast lesions and hence can be a source of diagnostic pitfall. We present a case of an MFB of the breast in a 55-year-old female, which was detected on a routine screening mammography. Fine-needle aspiration cytology was inconclusive. Final diagnosis was made by histopathology and immunohistochemistry examination. We report this case as the likelihood of encountering MFB has increased in recent years due to routine mammographic screening, and this lesion should be kept in the differential diagnosis of spindle-cell lesions of the breast.

Keywords: Myofibroblastoma; postmenopausal woman; spindle cell tumor.

PubMed Disclaimer

Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
(a) Mammogram showing well-defined soft-tissue density in retroareolar region (arrow) of the right breast. (b) Scanner view showing a well-circumscribed tumor, (H and E, ×40). (c) Low-power view showing a tumor composed of fascicles of benign spindle cells, (H and E, ×100). (d) High-power showing tumor cells interspersed with ropy collagen (H and E ×400)
Figure 2
Figure 2
(a) Tumor cells showing CD34 positivity (IHC ×100). (b) Tumor cells showing smooth muscle actin positivity (IHC ×100)
See this image and copyright information in PMC

References

    1. McMenamin ME, Fletcher CD. Mammary-type myofibroblastoma of soft tissue: A tumor closely related to spindle cell lipoma. Am J Surg Pathol. 2001;25:1022–9. - PubMed
    1. Wargotz ES, Weiss SW, Norris HJ. Myofibroblastoma of the breast. Sixteen cases of a distinctive benign mesenchymal tumor. Am J Surg Pathol. 1987;11:493–502. - PubMed
    1. Magro G. Mammary myofibroblastoma: An update with emphasis on the most diagnostically challenging variants. Histol Histopathol. 2016;31:1–23. - PubMed
    1. Magro G. Mammary myofibroblastoma: A tumor with a wide morphologic spectrum. Arch Pathol Lab Med. 2008;132:1813–20. - PubMed
    1. Toker C, Tang CK, Whitely JF, Berkheiser SW, Rachman R. Benign spindle cell breast tumor. Cancer. 1981;48:1615–22. - PubMed

Publication types