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Review
. 2018 Mar 27:10:615-624.
doi: 10.2147/CMAR.S133291. eCollection 2018.

Management of relapsed/refractory marginal zone lymphoma: focus on ibrutinib

Nathan M Denlinger  1 , Narendranath Epperla  1 , Basem M William  1
Affiliations
Review

Management of relapsed/refractory marginal zone lymphoma: focus on ibrutinib

Nathan M Denlinger et al. Cancer Manag Res. .

Abstract

Marginal zone lymphomas (MZLs) consist of a diverse family of malignancies, which are derived from B-cells. The disease subtypes are recognized extranodal, nodal, and splenic MZLs. The disease characteristics, clinical course, and treatment vary considerably based on the site of involvement. In 2017, the US Food and Drug Administration approved ibrutinib, a first in class Bruton's tyrosine kinase inhibitor that revolutionized the care of chronic lymphocytic leukemia patients; for, the treatment of relapsed/refractory MZL based on pivotal open-label Phase II trial demonstrated an overall response rate of 48%, with a complete response rate of 3%, median progression-free survival of 14.2 months, and median overall survival not yet reached at a median follow-up of 19.4 months. In this review, we aim to summarize the current conundrums in the management of MZL and the evolving role of ibrutinib in the treatment of MZL.

Keywords: ibrutinib; marginal zone; non-Hodgkin’s lymphoma.

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Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

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