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. 1988 Jan 25;227(2):136-40.
doi: 10.1016/0014-5793(88)80884-6.

Starvation or diabetes decreases the content but not the mRNA of 6-phosphofructo-2-kinase in rat liver

K M Crepin  1 , M I Darville, L Hue, G G Rousseau
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Free article

Starvation or diabetes decreases the content but not the mRNA of 6-phosphofructo-2-kinase in rat liver

K M Crepin et al. FEBS Lett. .
Free article

Abstract

In rat liver, the activity of 6-phosphofructo-2-kinase (PFK-2) decreases upon starvation and in diabetes. Cyclic AMP-dependent phosphorylation of the enzyme is not sufficient to account for this decrease. PFK-2 content was therefore measured by immunotitration and relative PFK-2 mRNA levels were determined by hybridization with cDNA probes. The data are compatible with a posttranscriptional mechanism of regulation that involves decreased translational efficiency of PFK-2 mRNA and (or) increased turnover of the PFK-2 protein.

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