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. 2018 Mar;61(3):90-94.
doi: 10.3345/kjp.2018.61.3.90. Epub 2018 Mar 19.

Association between vitamin D and urinary tract infection in children

Abolfazl Mahyar  1 , Parviz Ayazi  1 , Sara Safari  1 , Reza Dalirani  2 , Amir Javadi  3 , Shiva Esmaeily  3
Affiliations

Association between vitamin D and urinary tract infection in children

Abolfazl Mahyar et al. Korean J Pediatr. 2018 Mar.

Abstract

Purpose: The present study aimed to determine the relationship between serum 25-hydroxyvitamin D (25(OH)D) level and Urinary tract infections (UTIs) in children.

Methods: In this case-control study, 70 children with UTI (case group) were compared with 70 healthy children (control group) in terms of serum 25(OH)D levels. The children were between 1 month and 12 years of age. Serum 25(OH)D levels were measured using enzyme-linked immunosorbent assay (ELISA). The results were analyzed and compared between both groups.

Results: Among 70 children with UTI (case group), 5 children (7.2%) were male and 65 (92.8%) were female. Among the healthy children (control group), 9 (12.8%) and 61 children (87.2%) were male and female, respectively (P=0.39). The mean±standard deviation of age in the case and control groups were 53.2±35.6 and 36.1±60.2 months, respectively (P=0.24). The mean level of serum 25(OH)D in the case group was significantly higher than that of the control group (20.4±8.6 ng/mL vs. 16.9±7.4 ng/mL, P=0.01).

Conclusion: This study showed that there was a relationship between serum 25(OH)D levels and UTI in children. It seems that 25(OH)D plays a role in the pathogenesis of UTI.

Keywords: 25-Hydroxyvitamin D; Child; Urinary tract infection.

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Conflict of interest statement

Conflicts of interest: No potential conflict of interest relevant to this article was reported.

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