Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018:4:12.
doi: 10.1051/sicotj/2017028. Epub 2018 Apr 9.

Osteosarcoma: a comprehensive review

Amirhossein Misaghi  1 , Amanda Goldin  1 , Moayd Awad  2 , Anna A Kulidjian  1
Affiliations

Osteosarcoma: a comprehensive review

Amirhossein Misaghi et al. SICOT J. 2018.

Abstract

Osteosarcoma (OS) is a relatively rare tumor of bone with a worldwide incidence of 3.4 cases per million people per year. For most of the twentieth century, five-year survival rates for classic OS were very low. In the 1970s, the introduction of adjuvant chemotherapy in the treatment of OS increased survival rates dramatically. The current article reviews the various types of OS and analyzes the clinical and histological features. We also examine historical and current literature to present a succinct review of methods for diagnosis and staging, as well as treatment, and we also discuss some of the future directions of treatment.

PubMed Disclaimer

References

    1. Mirabello L, Troisi RJ, Savage SA (2009) International osteosarcoma incidence patterns in children and adolescents, middle ages and elderly persons. Int J Cancer 125, 229–234. - PMC - PubMed
    1. Harvei S, Solheim Ø (1981) The prognosis in osteosarcoma: Norwegian national data. Cancer 48, 1719–1723. - PubMed
    1. Sutow WW, Sullivan MP, Fernbach DJ, Cangir A, George SL (1975) Adjuvant chemotherapy in primary treatment of osteogenic sarcoma. A Southwest Oncology Group study. Cancer 36, 1598–1602. - PubMed
    1. Eilber ByF, Giuliano A, Eckardt J, Patterson K, Moseley S, Goodnight J (1987) Adjuvant chemotherapy for osteosarcoma: a randomized prospective trial. J Clin Oncol 5, 21–26. - PubMed
    1. Simon MA, Aschilman MA, Thomas N, Mankin HJ (1986) Limb-salvage treatment versus amputation for osteosarcoma of the distal end of the femur. J Bone Joint Surg Am 68, 1331–1337. - PubMed