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Comment
. 2018 May;18(5):294-295.
doi: 10.1038/nri.2018.27. Epub 2018 Apr 9.

Immunometabolism: Itaconate helps KEAP1's cool

Grant Otto
Comment

Immunometabolism: Itaconate helps KEAP1's cool

Grant Otto. Nat Rev Immunol. 2018 May.
No abstract available

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Comment on

  • Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
    Mills EL, Ryan DG, Prag HA, Dikovskaya D, Menon D, Zaslona Z, Jedrychowski MP, Costa ASH, Higgins M, Hams E, Szpyt J, Runtsch MC, King MS, McGouran JF, Fischer R, Kessler BM, McGettrick AF, Hughes MM, Carroll RG, Booty LM, Knatko EV, Meakin PJ, Ashford MLJ, Modis LK, Brunori G, Sévin DC, Fallon PG, Caldwell ST, Kunji ERS, Chouchani ET, Frezza C, Dinkova-Kostova AT, Hartley RC, Murphy MP, O'Neill LA. Mills EL, et al. Nature. 2018 Apr 5;556(7699):113-117. doi: 10.1038/nature25986. Epub 2018 Mar 28. Nature. 2018. PMID: 29590092 Free PMC article.

References

    1. Nature. 2018 Apr 5;556(7699):113-117 - PubMed

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