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Review
. 2018 Jun;18(3):243-247.
doi: 10.1097/ACI.0000000000000442.

How to manage food dependent exercise induced anaphylaxis (FDEIA)

Tomoyuki Asaumi  1 , Motohiro Ebisawa  2
Affiliations
Review

How to manage food dependent exercise induced anaphylaxis (FDEIA)

Tomoyuki Asaumi et al. Curr Opin Allergy Clin Immunol. 2018 Jun.

Abstract

Purpose of review: In recent years, the number of reports on food-dependent exercise-induced anaphylaxis (FDEIA) has been increasing. This review aims to describe the standard management of FDEIA including provocation tests and identify the issues that remain unclear.

Recent findings: Provocation tests with aspirin for FDEIA enable us to confirm the definitive diagnosis and to make differential diagnosis. In some cases, FDEIA symptoms can be induced by aspirin and the causative food without exercise. Exercise may only be an augmenting factor of FDEIA, similar to aspirin or alcohol.

Summary: The mechanisms of FDEIA development remain unclear. It has been suggested that in FDEIA, exercise lowers the threshold of a food allergy. Further research is needed to elucidate the mechanism of FDEIA and to establish strategies for effective disease management.

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