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Book

Dermatitis Herpetiformis

Huma A. Mirza  1 , Amani Gharbi  2 , Beenish S. Bhutta  3
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
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Book

Dermatitis Herpetiformis

Huma A. Mirza et al.
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Excerpt

Dermatitis herpetiformis is a chronic, autoimmune, blistering disease that causes an extremely pruritic rash that predominantly affects the extensor surfaces. The characteristic vesicles are often not apparent as they are destroyed by excoriation. The disease is closely associated with gluten-sensitive enteropathy (GSE); both conditions are characterized by the development of IgA autoantibodies against transglutaminases that, in the case of dermatitis herpetiformis, are deposited in the superficial papillary dermis. Therapy involves strict gluten avoidance and the use of sulphonamide drugs such as dapsone.

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Conflict of interest statement

Disclosure: Huma Mirza declares no relevant financial relationships with ineligible companies.

Disclosure: Amani Gharbi declares no relevant financial relationships with ineligible companies.

Disclosure: Beenish Bhutta declares no relevant financial relationships with ineligible companies.

References

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    1. Varpuluoma O, Jokelainen J, Försti AK, Timonen M, Huilaja L, Tasanen K. Dermatitis Herpetiformis and Celiac Disease Increase the Risk of Bullous Pemphigoid. J Invest Dermatol. 2019 Mar;139(3):600-604. - PubMed
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    1. Graziano M, Rossi M. An update on the cutaneous manifestations of coeliac disease and non-coeliac gluten sensitivity. Int Rev Immunol. 2018;37(6):291-300. - PubMed

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