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Book

Opioid-Induced Constipation

Omeed Sizar  1 , Rafaella Genova  2 , Mohit Gupta  3
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
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Book

Opioid-Induced Constipation

Omeed Sizar et al.
Free Books & Documents

Excerpt

Opioid-induced constipation (OIC) accounts from over 40% to 60% in patients without cancer receiving opioids. Laxatives must be started at the same time as the opioid to prevent OIC. Once the disorder is established, treatment involves both pharmacological and nonpharmacological therapies. OIC may present immediately when a patient takes the opioid, or it may present gradually during opioid therapy. In association with constipation, patients may also develop other GI side effects like nausea, vomiting, bloat, abdominal pain, and straining. Many patients who develop constipation following opioids stop the drug therapy because they simply cannot tolerate the adverse effects on the GI tract. Once constipation to opioids has developed, the relief with treatment is slow and does not always result in optimal relief from constipation.

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Conflict of interest statement

Disclosure: Omeed Sizar declares no relevant financial relationships with ineligible companies.

Disclosure: Rafaella Genova declares no relevant financial relationships with ineligible companies.

Disclosure: Mohit Gupta declares no relevant financial relationships with ineligible companies.

References

    1. Coyne KS, Margolis MK, Yeomans K, King FR, Chavoshi S, Payne KA, LoCasale RJ. Opioid-Induced Constipation Among Patients with Chronic Noncancer Pain in the United States, Canada, Germany, and the United Kingdom: Laxative Use, Response, and Symptom Burden Over Time. Pain Med. 2015 Aug;16(8):1551-65. - PubMed
    1. Imam MZ, Kuo A, Ghassabian S, Smith MT. Progress in understanding mechanisms of opioid-induced gastrointestinal adverse effects and respiratory depression. Neuropharmacology. 2018 Mar 15;131:238-255. - PubMed
    1. Andresen V, Layer P. Medical Therapy of Constipation: Current Standards and Beyond. Visc Med. 2018 Apr;34(2):123-127. - PMC - PubMed
    1. Farmer AD, Holt CB, Downes TJ, Ruggeri E, Del Vecchio S, De Giorgio R. Pathophysiology, diagnosis, and management of opioid-induced constipation. Lancet Gastroenterol Hepatol. 2018 Mar;3(3):203-212. - PubMed
    1. Luthra P, Burr NE, Brenner DM, Ford AC. Efficacy of pharmacological therapies for the treatment of opioid-induced constipation: systematic review and network meta-analysis. Gut. 2019 Mar;68(3):434-444. - PubMed

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