Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Book

Generalized Pustular Psoriasis

Huma A. Mirza  1 , Haitham M. Saleh  2
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
Affiliations
Free Books & Documents
Book

Generalized Pustular Psoriasis

Huma A. Mirza et al.
Free Books & Documents

Excerpt

Pustular psoriasis is a rare and severe variant of psoriasis characterized by the eruption of sterile pustules, which may present in distinct clinical patterns. The pathologic features of psoriasis, including keratinocyte hyperproliferation, neutrophilic infiltration, and immune dysregulation, are markedly accentuated. Generalized pustular psoriasis (GPP) displays clinical heterogeneity in age of onset, severity, and disease course. Several overlapping phenotypes are recognized. A variable relationship exists between GPP and plaque psoriasis. Some individuals experience plaque psoriasis before or after GPP episodes, while others exhibit GPP as the sole phenotype without any history of plaque involvement (see Image. Pustular Psoriasis).

PubMed Disclaimer

Conflict of interest statement

Disclosure: Huma Mirza declares no relevant financial relationships with ineligible companies.

Disclosure: Haitham Saleh declares no relevant financial relationships with ineligible companies.

References

    1. Nagai M, Imai Y, Wada Y, Kusakabe M, Yamanishi K. Serum Procalcitonin and Presepsin Levels in Patients with Generalized Pustular Psoriasis. Dis Markers. 2018;2018:9758473. - PMC - PubMed
    1. Peccerillo F, Odorici G, Ciardo S, Conti A, Pellacani G. Evaluation of generalized pustular psoriasis by reflectance confocal microscopy. Skin Res Technol. 2019 May;25(3):402-403. - PubMed
    1. Akiyama M. Early-onset generalized pustular psoriasis is representative of autoinflammatory keratinization diseases. J Allergy Clin Immunol. 2019 Feb;143(2):809-810. - PubMed
    1. Cassandra M, Conte E, Cortez B. Childhood pustular psoriasis elicited by the streptococcal antigen: a case report and review of the literature. Pediatr Dermatol. 2003 Nov-Dec;20(6):506-10. - PubMed
    1. Brenner M, Molin S, Ruebsam K, Weisenseel P, Ruzicka T, Prinz JC. Generalized pustular psoriasis induced by systemic glucocorticosteroids: four cases and recommendations for treatment. Br J Dermatol. 2009 Oct;161(4):964-6. - PubMed

Publication types

LinkOut - more resources