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Observational Study
. 2018 May 1;178(5):632-639.
doi: 10.1001/jamainternmed.2018.0514.

Sex Differences in Outcomes After STEMI: Effect Modification by Treatment Strategy and Age

Edina Cenko  1 , Jinsung Yoon  2 , Sasko Kedev  3 , Goran Stankovic  4 , Zorana Vasiljevic  5 , Gordana Krljanac  4 , Oliver Kalpak  3 , Beatrice Ricci  1 , Davor Milicic  6 , Olivia Manfrini  1 , Mihaela van der Schaar  2 , Lina Badimon  7 , Raffaele Bugiardini  1
Affiliations
Observational Study

Sex Differences in Outcomes After STEMI: Effect Modification by Treatment Strategy and Age

Edina Cenko et al. JAMA Intern Med. .

Abstract

Importance: Previous works have shown that women hospitalized with ST-segment elevation myocardial infarction (STEMI) have higher short-term mortality rates than men. However, it is unclear if these differences persist among patients undergoing contemporary primary percutaneous coronary intervention (PCI).

Objective: To investigate whether the risk of 30-day mortality after STEMI is higher in women than men and, if so, to assess the role of age, medications, and primary PCI in this excess of risk.

Design, setting, and participants: From January 2010 to January 2016, a total of 8834 patients were hospitalized and received medical treatment for STEMI in 41 hospitals referring data to the International Survey of Acute Coronary Syndromes in Transitional Countries (ISACS-TC) registry (NCT01218776).

Exposures: Demographics, baseline characteristics, clinical profile, and pharmacological treatment within 24 hours and primary PCI.

Main outcomes and measures: Adjusted 30-day mortality rates estimated using inverse probability of treatment weighted (IPTW) logistic regression models.

Results: There were 2657 women with a mean (SD) age of 66.1 (11.6) years and 6177 men with a mean (SD) age of 59.9 (11.7) years included in the study. Thirty-day mortality was significantly higher for women than for men (11.6% vs 6.0%, P < .001). The gap in sex-specific mortality narrowed if restricting the analysis to men and women undergoing primary PCI (7.1% vs 3.3%, P < .001). After multivariable adjustment for comorbidities and treatment covariates, women under 60 had higher early mortality risk than men of the same age category (OR, 1.88; 95% CI, 1.04-3.26; P = .02). The risk in the subgroups aged 60 to 74 years and over 75 years was not significantly different between sexes (OR, 1.28; 95% CI, 0.88-1.88; P = .19 and OR, 1.17; 95% CI, 0.80-1.73; P = .40; respectively). After IPTW adjustment for baseline clinical covariates, the relationship among sex, age category, and 30-day mortality was similar (OR, 1.56 [95% CI, 1.05-2.3]; OR, 1.49 [95% CI, 1.15-1.92]; and OR, 1.21 [95% CI, 0.93-1.57]; respectively).

Conclusions and relevance: Younger age was associated with higher 30-day mortality rates in women with STEMI even after adjustment for medications, primary PCI, and other coexisting comorbidities. This difference declines after age 60 and is no longer observed in oldest women.

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Conflict of interest statement

Conflict of Interest Disclosures: None reported.

Figures

Figure 1.
Figure 1.. Distributions of Time From Symptoms Onset to Admission of ≤2 Hours
P value for comparison between women and men in the same age category.
Figure 2.
Figure 2.. Unadjusted 30-Day Mortality Rates in Age Categories Sorted by Sex
Abbreviations: PCI, percutaneous coronary interventions; STEMI, ST-segment elevation myocardial infarction.
See this image and copyright information in PMC

References

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