Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2018 Apr 9;8(1):5686.
doi: 10.1038/s41598-018-23403-5.

Positive Surgical Margins in the 10 Most Common Solid Cancers

Ryan K Orosco  1 , Viridiana J Tapia  1 , Joseph A Califano  1   2   3 , Bryan Clary  2 , Ezra E W Cohen  3   4 , Christopher Kane  3   5 , Scott M Lippman  3   4 , Karen Messer  3 , Alfredo Molinolo  3 , James D Murphy  6 , John Pang  1 , Assuntina Sacco  3   4 , Kathryn R Tringale  1 , Anne Wallace  2   3 , Quyen T Nguyen  7   8   9   10
Affiliations
Comparative Study

Positive Surgical Margins in the 10 Most Common Solid Cancers

Ryan K Orosco et al. Sci Rep. .

Abstract

A positive surgical margin (PSM) following cancer resection oftentimes necessitates adjuvant treatments and carries significant financial and prognostic implications. We sought to compare PSM rates for the ten most common solid cancers in the United States, and to assess trends over time. Over 10 million patients were identified in the National Cancer Data Base from 1998-2012, and 6.5 million had surgical margin data. PSM rates were compared between two time periods, 1998-2002 and 2008-2012. PSM was positively correlated with tumor category and grade. Ovarian and prostate cancers had the highest PSM prevalence in women and men, respectively. The highest PSM rates for cancers affecting both genders were seen for oral cavity tumors. PSM rates for breast cancer and lung and bronchus cancer in both men and women declined over the study period. PSM increases were seen for bladder, colon and rectum, and kidney and renal pelvis cancers. This large-scale analysis appraises the magnitude of PSM in the United States in order to focus future efforts on improving oncologic surgical care with the goal of optimizing value and improving patient outcomes.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Positive surgical margin (PSM) prevalence (reported as rate per 10,000 patients) for each cancer in women (A) and men (B) as a function of time.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA Cancer J Clin. 2016;66:7–30. doi: 10.3322/caac.21332. - DOI - PubMed
    1. National Comprehensive Cancer Network. Clinical Practice Guidelines in Oncology. Version 2.2016, https://www.nccn.org/professionals/physician_gls/f_guidelines.asp-site (2016).
    1. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin. 2012;62:10–29. doi: 10.3322/caac.20138. - DOI - PubMed
    1. Deyo RA, Cherkin DC, Ciol MA. Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. J Clin Epidemiol. 1992;45:613–619. doi: 10.1016/0895-4356(92)90133-8. - DOI - PubMed
    1. McCahill LE, et al. Variability in reexcision following breast conservation surgery. JAMA. 2012;307:467–475. doi: 10.1001/jama.2012.43. - DOI - PubMed

Publication types