Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Dec;22(6):1281-1293.
doi: 10.1007/s10157-018-1571-5. Epub 2018 Apr 9.

Transition from acute kidney injury to chronic kidney disease: a single-centre cohort study

Yutaka Hatakeyama  1 , Taro Horino  2 , Keitaro Nagata  1 , Tatsuki Matsumoto  3 , Yoshio Terada  3 , Yoshiyasu Okuhara  1
Affiliations

Transition from acute kidney injury to chronic kidney disease: a single-centre cohort study

Yutaka Hatakeyama et al. Clin Exp Nephrol. 2018 Dec.

Abstract

Background: The incidence of acute kidney injury (AKI) is increasing. AKI is currently recognised as an inducer of chronic kidney disease (CKD) and this is known as the 'AKI-CKD transition'. This study aimed to evaluate the rate of decline in estimated glomerular filtration rate (eGFR) associated with AKI events in individuals with and without pre-existing CKD.

Methods: Inpatients aged 18-80 years were retrospectively enrolled. AKI was diagnosed according to the kidney disease improving global outcomes (KDIGO) criteria using serum creatinine levels. Patients with a history of AKI events were divided into four groups according to eGFR before and after the AKI events. In each group, the eGFR levels after an AKI event were compared to those before the AKI event. Patients were further divided into eight groups according to clinical background based on underlying diseases, medications, and surgical history.

Results: We analysed data from 9651 patients with AKI. Not surprisingly, we found that eGFR levels during the first AKI event were significantly lower than levels before the event in each group. Furthermore, eGFR levels after the first AKI event were significantly lower than those before the first AKI event, and the eGFR levels after the second AKI event were significantly lower than those after the first AKI event. These trends were similar in each group irrespective of clinical background.

Conclusions: Our study revealed that AKI events can cause a decline in kidney function and, as more AKI events occur, acceleration of this decline.

Keywords: AKI–CKD transition; Acute kidney injury (AKI); Chronic kidney disease (CKD); KDIGO; Medical database.

PubMed Disclaimer

References

    1. N Engl J Med. 1956 May 31;254(22):1023-6 - PubMed
    1. Am J Kidney Dis. 2009 Jun;53(6):982-92 - PubMed
    1. Kidney Int. 2007 Apr;71(7):679-86 - PubMed
    1. Lancet. 1952 May 31;1(6718):1086-8 - PubMed
    1. Clin Exp Nephrol. 2016 Apr;20(2):235-43 - PubMed