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Comment
. 2018 Apr 9;45(1):3-5.
doi: 10.1016/j.devcel.2018.03.005.

Metastasis of Circulating Tumor Cells: Speed Matters

Vanessa Morais Freitas  1 , Georg Hilfenhaus  1 , M Luisa Iruela-Arispe  2
Affiliations
Comment

Metastasis of Circulating Tumor Cells: Speed Matters

Vanessa Morais Freitas et al. Dev Cell. .

Abstract

The mechanisms involved in tumor cell extravasation during metastasis remain incompletely understood. In this issue of Developmental Cell, Follain and colleagues (2018) demonstrate that blood flow velocity is an important regulator of circulating tumor cell exit from the bloodstream.

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Figures

Figure 1.
Figure 1.. Permissive Blood Flow Facilitates Arrest and Extravasation of CTCs
Brain metastases are located in regions presenting lower blood flow rates, compatible with smaller vessel size (A). Low flow rate, found on vessels modulated by lidocaine, allows CTCs to arrest and adhere, but not to extravasate (B, upper vessel). Intermediate flow rates are required to permit endothelial remodeling (pocketing) and CTC extravasation beyond arrest and adhesion (B, lower vessel). High blood flow in larger vessels prevents cell arrest and subsequent extravasation (C).
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Comment on

  • Hemodynamic Forces Tune the Arrest, Adhesion, and Extravasation of Circulating Tumor Cells.
    Follain G, Osmani N, Azevedo AS, Allio G, Mercier L, Karreman MA, Solecki G, Garcia Leòn MJ, Lefebvre O, Fekonja N, Hille C, Chabannes V, Dollé G, Metivet T, Hovsepian F, Prudhomme C, Pichot A, Paul N, Carapito R, Bahram S, Ruthensteiner B, Kemmling A, Siemonsen S, Schneider T, Fiehler J, Glatzel M, Winkler F, Schwab Y, Pantel K, Harlepp S, Goetz JG. Follain G, et al. Dev Cell. 2018 Apr 9;45(1):33-52.e12. doi: 10.1016/j.devcel.2018.02.015. Dev Cell. 2018. PMID: 29634935

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