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Review
. 2019 Sep:113:67-74.
doi: 10.1016/j.molimm.2018.03.027. Epub 2018 Apr 7.

Antigen processing and presentation in HIV infection

Julie Boucau  1 , Sylvie Le Gall  2
Affiliations
Review

Antigen processing and presentation in HIV infection

Julie Boucau et al. Mol Immunol. 2019 Sep.

Abstract

The presentation of virus-derived peptides by MHC molecules constitutes the earliest signals for immune recognition by T cells. In HIV infection, immune responses elicited during infection do not enable to clear infection and correlates of immune protection are not well defined. Here we review features of antigen processing and presentation specific to HIV, analyze how HIV has adapted to the antigen processing machinery and discuss how advances in biochemical and computational protein degradation analyses and in immunopeptidome definition may help identify targets for efficient immune clearance and vaccine immunogen design.

Keywords: HIV; Immune escape; Immunopeptidome; Protein degradation; T cells; Vaccine immunogen design.

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