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. 2018 Mar 27:12:78.
doi: 10.3389/fncel.2018.00078. eCollection 2018.

Epigenetics and Autism Spectrum Disorder: Is There a Correlation?

Adrien A Eshraghi  1 , George Liu  1 , Sae-In Samantha Kay  2 , Rebecca S Eshraghi  3 , Jeenu Mittal  1 , Baharak Moshiree  3 , Rahul Mittal  1
Affiliations

Epigenetics and Autism Spectrum Disorder: Is There a Correlation?

Adrien A Eshraghi et al. Front Cell Neurosci. .
No abstract available

Keywords: DNA methylation; autism spectrum disorder; epigenetics; histone; microRNAs; transgenerational inheritance.

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Figures

Figure 1
Figure 1
Schematic representation of Epigenetic mechanisms that can influence the genetic etiology. Histone modification can occur via either acylation or methylation of histone tail. (1) Acylation of histone tail leads to uncoiling of nucleosome, activating the gene and revealing DNA content to be modified. (2) On the other hand, methylation of histone tail coils nucleosomes tightly together, inactivating the gene and making DNA inaccessible for further modifications. (3) Methylation can also occur via binding methyl group to cytosine, suppressing transcription of certain genes. (Adapted from https://commonfund.nih.gov/epigenomics/figure).
See this image and copyright information in PMC

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