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. 2017 Jul 3;1(1):e000023.
doi: 10.1136/bmjpo-2017-000023. eCollection 2017.

Plasma citrate concentration: a possible biomarker for glaucoma in children

Marta Michalczuk  1 , Porowski Tadeusz  2 , Beata Urban  1 , Wasilewska Anna  2 , Alina Bakunowicz-Łazarczyk  1
Affiliations

Plasma citrate concentration: a possible biomarker for glaucoma in children

Marta Michalczuk et al. BMJ Paediatr Open. .

Abstract

Objectives: The main aim of the present study was to examine a possible role of plasma and urine citrate levels as glaucoma indicators in school-aged children with glaucoma diagnosis.

Patients: 34 school-aged children with a glaucoma diagnosis (mean age 15.69±1.86 years) were qualified for the study group and 34 patients with no ophthalmological ailments were qualified for the control group (mean age 16.1±1.98 years). Plasma and urine citrate levels in the study and the control group (Kruskal-Wallis test) were compared.

Results: Plasma citrate levels in the study (16.33±4.51 mg/L) and the control group (19.11±3.66 mg/L) were different; the statistical significance (p=0.0036). Plasma citrate concentrations were significantly lower in the study group in comparison with the control group. There were no statistically important differences between the study group (291.12±259.13 mg/24 hours; 275.82±217.57 mg/g) and the control group (434.88±357.66 mg/24 hours; 329.81±383.27 mg/g) including urine citrate level (p=0.052) and urine citrate to creatine ratio (p=0.4667).

Conclusion: Plasma citrate concentration might be considered as glaucoma biomarker in paediatric population.

Keywords: Ophthalmology; screening.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Whiskers diagrams highlight plasma citrate level differences between test and control group.
See this image and copyright information in PMC

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