Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Nov;33(7):423-432.
doi: 10.1177/1533317518768999. Epub 2018 Apr 11.

Use of Potentially Inappropriate Medications in People With Dementia in Vietnam and Its Associated Factors

Tuan Anh Nguyen  1 , Thang Pham  2 , Huyen Thi Thanh Vu  2 , Thanh Xuan Nguyen  2 , Trinh Thi Vu  2 , Binh Thi Thanh Nguyen  2 , Ngoc Quynh Nguyen  2 , Binh Thanh Nguyen  2 , Binh Thanh Nguyen  2 , Tam Ngoc Nguyen  2 , Sinh Viet Phan  2 , Anh Trung Nguyen  2 , Tuan Le Pham  3 , Ha Thu Dang  1 , Lisa Kalisch-Ellett  1 , Marianne Gillam  1 , Nicole Pratt  1 , Sun Qiang  4 , Haipeng Wang  4 , Tipaporn Kanjanarach  5 , Mohamed Azmi Ahmad Hassali  6 , Zaheer-Ud-Din Babar  7 , Asrenee Ab Razak  8 , Dujrudee Chinwong  9 , Elizabeth E Roughead  1
Affiliations

Use of Potentially Inappropriate Medications in People With Dementia in Vietnam and Its Associated Factors

Tuan Anh Nguyen et al. Am J Alzheimers Dis Other Demen. 2018 Nov.

Abstract

This study examined the use of potentially inappropriate medicines that may affect cognition (PIMcog) in people with dementia and its associated factors. Medical records of all outpatients with dementia attending a tertiary hospital in Vietnam between January 1, 2015, and December 31, 2016, were examined. Medicine use was assessed against a list of PIMcog. Variables associated with having a PIMcog were assessed using a multiple logistic regression. Of the 128 patients, 41% used a PIMcog, 39.1% used cholinesterase inhibitors (CEIs) concomitantly with anticholinergics, and 18% used antipsychotics. The number of hospital visits (adjusted odds ratio [OR]: 1.08; 95% confidence interval [CI]: 1.02-1.16) and number of treating specialists (adjusted OR: 0.61; 95% CI: 0.45-0.83) were associated with PIMcog use. This study highlights a high-level use of medicines that can further impair cognition or reduce the effectiveness of CEIs in people with dementia. Efforts to improve quality use of medicines for this population are warranted.

Keywords: anticholinergics; antipsychotics; dementia; potentially inappropriate medicines; quality use of medicines; sedatives.

PubMed Disclaimer

Conflict of interest statement

The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Prince M, Wimo A, Guerchet M, Ali GC, Wu YT, Prina M. World Alzheimer Report 2015. The global impact of dementia: an analysis of prevalence, incidence, cost and trends. London, UK: Alzheimer’s disease international; 2015.
    1. Prince M, Comas-Herrera A, Knapp M, Guerchet M, Karagiannidou M. World Alzheimer Report 2016. Improving healthcare for people living with dementia: coverage, quality and costs now and in the future. London, UK: Alzheimer’s disease international; 2016.
    1. United Nations - Department of economic and social affairs - population division. World Population Prospects: 2015 revision. New York: United Nations; 2015.
    1. Le TV. Epidemiological features of dementia in older people in two districts of Hanoi [Thesis]. Hanoi, Vietnam: national institute of hygiene and epidemiology; 2014.
    1. Nguyen VK. A study of dementia characteristics in community. J Br Med. 2009;10(679):16–18.

Publication types

MeSH terms

Substances