Usefulness of Kaposi's Sarcoma-Associated Herpesvirus (KSHV) DNA Viral Load in Whole Blood for Diagnosis and Monitoring of KSHV-Associated Diseases

Aude Jary¹, Valentin Leducq², Romain Palich³, Adélie Gothland², Diane Descamps⁴, Véronique Joly⁵, Sidonie Lambert-Niclot⁶, Corinne Amiel⁷, Ana Canestri⁸, Audrey Mirand⁹, Elyanne Gault¹⁰, Astrid Vabret¹¹, Marc-Antoine Valantin³, Christine Katlama³, Vincent Calvez², Nicolas Dupin¹², Jean-Philippe Spano¹³, Anne-Geneviève Marcelin¹

Affiliations

¹ Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), AP-HP, Hôpital Pitié Salpêtrière, Laboratoire de virologie, Paris, France aude.jary@aphp.fr anne-genevieve.marcelin@aphp.fr.
² Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), AP-HP, Hôpital Pitié Salpêtrière, Laboratoire de virologie, Paris, France.
³ Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), AP-HP, Hôpital Pitié Salpêtrière, Service de Maladies Infectieuses et Tropicale, Paris, France.
⁴ IAME, UMR 1137, INSERM, Université Paris Diderot, Sorbonne Paris Cité, AP-HP, Service de Virologie, Hôpital Bichat, AP-HP, Paris, France.
⁵ IAME, UMR 1137, INSERM, Université Paris Diderot, Sorbonne Paris Cité, AP-HP, Service de Maladies Infectieuses et Tropicales, Hôpital Bichat, AP-HP, Paris, France.
⁶ Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), AP-HP, Hôpital Saint Antoine, Service de Virologie, Paris, France.
⁷ Service de Virologie, AP-HP Hôpital Tenon, Paris, France.
⁸ Service de Maladies Infectieuses et Tropicale, AP-HP Hôpital Tenon, Paris, France.
⁹ Service de Virologie, CHU Clermont-Ferrand, Clermont-Ferrand, France.
¹⁰ Service de Microbiologie-Hygiène, AP-HP Hôpital Ambroise Paré, Boulogne-Billancourt, France.
¹¹ Service de Virologie, CHU Caen, Caen, France.
¹² Service de Dermatologie, Hôpital Tarnier, GH Cochin-Port Royal, Paris, France.
¹³ Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), AP-HP, Hôpital Pitié Salpêtrière, Service d'Oncologie Médicale, Paris, France.

PMID: 29643199
PMCID: PMC5971550
DOI: 10.1128/JCM.00569-18

Usefulness of Kaposi's Sarcoma-Associated Herpesvirus (KSHV) DNA Viral Load in Whole Blood for Diagnosis and Monitoring of KSHV-Associated Diseases

Aude Jary et al. J Clin Microbiol. 2018.

. 2018 May 25;56(6):e00569-18.

doi: 10.1128/JCM.00569-18. Print 2018 Jun.

Authors

Affiliations

¹ Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), AP-HP, Hôpital Pitié Salpêtrière, Laboratoire de virologie, Paris, France aude.jary@aphp.fr anne-genevieve.marcelin@aphp.fr.
² Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), AP-HP, Hôpital Pitié Salpêtrière, Laboratoire de virologie, Paris, France.
³ Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), AP-HP, Hôpital Pitié Salpêtrière, Service de Maladies Infectieuses et Tropicale, Paris, France.
⁴ IAME, UMR 1137, INSERM, Université Paris Diderot, Sorbonne Paris Cité, AP-HP, Service de Virologie, Hôpital Bichat, AP-HP, Paris, France.
⁵ IAME, UMR 1137, INSERM, Université Paris Diderot, Sorbonne Paris Cité, AP-HP, Service de Maladies Infectieuses et Tropicales, Hôpital Bichat, AP-HP, Paris, France.
⁶ Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), AP-HP, Hôpital Saint Antoine, Service de Virologie, Paris, France.
⁷ Service de Virologie, AP-HP Hôpital Tenon, Paris, France.
⁸ Service de Maladies Infectieuses et Tropicale, AP-HP Hôpital Tenon, Paris, France.
⁹ Service de Virologie, CHU Clermont-Ferrand, Clermont-Ferrand, France.
¹⁰ Service de Microbiologie-Hygiène, AP-HP Hôpital Ambroise Paré, Boulogne-Billancourt, France.
¹¹ Service de Virologie, CHU Caen, Caen, France.
¹² Service de Dermatologie, Hôpital Tarnier, GH Cochin-Port Royal, Paris, France.
¹³ Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), AP-HP, Hôpital Pitié Salpêtrière, Service d'Oncologie Médicale, Paris, France.

PMID: 29643199
PMCID: PMC5971550
DOI: 10.1128/JCM.00569-18

No abstract available

Keywords: DNA; Kaposi's sarcoma-associated diseases; Kaposi's sarcoma-associated herpesvirus; biomarker; whole blood.

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Figures

**FIG 1**
Levels of Kaposi's sarcoma-associated herpesvirus (KSHV) in whole-blood and effusion fluid samples from patients with Kaposi's sarcoma (KS), Castleman multicentric disease (MCD), and primary effusion lymphoma (PEL) at the time of KSHV-associated disease diagnosis. Horizontal lines indicate median values (m); crosses indicate average values; boxes indicate quartile 1 and quartile 3 values; whiskers indicate 95% confidence intervals; black circles indicate outliers. P values were determined using the Kruskal-Wallis test (****, P < 0.0001) or the Mann-Whitney U test (*, P < 0.016).

See this image and copyright information in PMC

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Usefulness of Kaposi's Sarcoma-Associated Herpesvirus (KSHV) DNA Viral Load in Whole Blood for Diagnosis and Monitoring of KSHV-Associated Diseases

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Usefulness of Kaposi's Sarcoma-Associated Herpesvirus (KSHV) DNA Viral Load in Whole Blood for Diagnosis and Monitoring of KSHV-Associated Diseases

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