Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Jan-Feb;34(1):204-208.
doi: 10.12669/pjms.341.11977.

Lack of association of statin use with vitamin D levels in a hospital based population of type 2 diabetes mellitus patients

Khalida Iqbal  1 , Najmul Islam  2 , Iqbal Azam  3 , Naseema Mehboobali  4 , Mohammad Perwaiz Iqbal  5
Affiliations

Lack of association of statin use with vitamin D levels in a hospital based population of type 2 diabetes mellitus patients

Khalida Iqbal et al. Pak J Med Sci. 2018 Jan-Feb.

Abstract

Objective: To investigate the relationship of statins (drug given to reduce serum levels of LDL-cholesterol) on vitamin D levels of Pakistani type 2 diabetes mellitus (DM) patients in a hospital in Karachi.

Methods: In a cross-sectional survey, 312 consecutive patients with type 2 DM (219 males and 93 females, age 22-70 years) were recruited with informed consent. A questionnaire was administered to find out whether they were statin users or non-users. Serum was analyzed for concentrations of 25(OH) vitamin D [25(OH)D] and other related biomarkers such as serum cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol, phosphate and calcium using kit methods. Multiple Linear Regression was used to evaluate association of statin use with serum levels of vitamin D while adjusting for related covariates including duration of statin use, duration of type 2 DM and smoking.

Results: Mean concentrations of serum cholesterol, and LDL-cholesterol were lower among statin users compared to statin non-users (P < 0.01), while HDL-cholesterol levels were higher (P<0.01). No relationship was observed between statin use and serum levels of vitamin D (P=0.768), when adjusted for age, gender, BMI, duration of type 2 DM, smoking, serum cholesterol and LDL-cholesterol. The adjusted regression coefficient (β) and standard error [SE(β)] for statin use duration were 0.012 (0.042), when serum levels of vitamin D was taken as an outcome.

Conclusion: Lack of association was found between statin use and vitamin D levels in a hospital-based population of Pakistani patients with type 2 DM.

Keywords: Diabetes mellitus; Pakistani population; Statins; Vitamin D levels.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: The authors declare that there are no conflicts of interest.

References

    1. Ray KK, Kastelein JJ, Boekholdt SM, Nicholls SJ, Khaw KT, Ballantyne CM, et al. The ACC/AHA 2013 guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular disease risk in adults: the good the bad and the uncertain: a comparison with ESC/EAS guidelines for the management of dyslipidaemias 2011. Eur Heart J. 2014;35:960–968. doi:10.1093/eurhearty/ehu107. - PubMed
    1. Taylor F, Huffman MD, Macedo AF, Moore TH, Burke M, Davey Smith G, et al. Statins for the primary prevention of cardiovascular disease. Cochrane Database Syst. 2013;Rev-1:CD004816. doi: 10.1002/14651858.CD004816.pub5. - PMC - PubMed
    1. Zittermann A, Gummert JF, Borgermann JH. The role of vitamin D in dyslipidemia and cardiovascular disease. Curr Pharm Des. 2011;17:933–942. - PubMed
    1. Weyland PG, Grant WB, Howie-Esquivel J. Does sufficient evidence exist to support a causal association between vitamin D status and cardiovascular disease risk? An assessment using Hill's criteria for causality. Nutrients. 2014;6:3403–3430. doi:10.3390/nu6093403. - PMC - PubMed
    1. Akhtar S. Vitamin D status of South Asian populations – risks and opportunities. Crit Rev Food Sci Nutr. 2016;56(11):1925–1940. doi:10.1080/10408398.2013.807419. - PubMed

LinkOut - more resources