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. 2018 Jun;29(6):1065-1074.
doi: 10.1007/s13361-018-1912-3. Epub 2018 Apr 11.

Cracking the Sugar Code by Mass Spectrometry : An Invited Perspective in Honor of Dr. Catherine E. Costello, Recipient of the 2017 ASMS Distinguished Contribution Award

Ekaterina Mirgorodskaya  1 , Niclas G Karlsson  2 , Carina Sihlbom  1 , Göran Larson  3 , Carol L Nilsson  4
Affiliations

Cracking the Sugar Code by Mass Spectrometry : An Invited Perspective in Honor of Dr. Catherine E. Costello, Recipient of the 2017 ASMS Distinguished Contribution Award

Ekaterina Mirgorodskaya et al. J Am Soc Mass Spectrom. 2018 Jun.

Abstract

The structural study of glycans and glycoconjugates is essential to assign their roles in homeostasis, health, and disease. Once dominated by nuclear magnetic resonance spectroscopy, mass spectrometric methods have become the preferred toolbox for the determination of glycan structures at high sensitivity. The patterns of such structures in different cellular states now allow us to interpret the sugar codes in health and disease, based on structure-function relationships. Dr. Catherine E. Costello was the 2017 recipient of the American Society for Mass Spectrometry's Distinguished Contribution Award. In this Perspective article, we describe her seminal work in a historical and geographical context and review the impact of her research accomplishments in the field.8 ᅟ Graphical abstract.

Keywords: Glycan mass spectrometry; History of mass spectrometry; Review; Structural mass spectrometry.

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Figures

None
ᅟ Graphical abstract
Figure 1
Figure 1
Fragmentation of an N-linked glycopeptide ECD (top) and IRMPD (bottom) demonstrate strict complementarity [68]
Figure 2
Figure 2
Oligosaccharide fragmentation nomenclature as developed by Domon and Costello [25]. The comprehensive system includes a code for dissociation between saccharide moieties as well as cross-ring fragmentation types
See this image and copyright information in PMC

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