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Review
. 2018 May;35(3):e173-e177.
doi: 10.1111/pde.13445. Epub 2018 Apr 11.

Perinuclear antineutrophil cytoplasmic antibody-positive vasculitis, oligoarthritis, tendinitis, and myositis associated with isotretinoin in a 15-year-old boy: Case report and review of literature

Thomas C Mangodt  1   2 , Rik Joos  1   3 , Vasiliki Siozopoulou  4 , Pieter-Jan Cortoos  5 , Hans Baeten  1   2 , Martine Docx  1   6 , Machiel van den Akker  1   7
Affiliations
Review

Perinuclear antineutrophil cytoplasmic antibody-positive vasculitis, oligoarthritis, tendinitis, and myositis associated with isotretinoin in a 15-year-old boy: Case report and review of literature

Thomas C Mangodt et al. Pediatr Dermatol. 2018 May.

Abstract

We present a patient in whom a combination of perinuclear antineutrophil cytoplasmic antibody-positive vasculitis, oligoarthritis, tendinitis, and myositis was considered to be associated with isotretinoin use. Discontinuation of the drug resulted in complete clinical and biochemical remission (normalization of perinuclear antineutrophil cytoplasmic antibody titer). Although we were unable to prove causality, no other underlying cause for the patient's course was found. We report this occurrence to bring it to the attention of physicians prescribing isotretinoin.

Keywords: arthritis; isotretinoin; myositis; p-ANCA; retinoid; tendinitis; vasculitis.

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