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. 2018 Apr 26;54(35):4406-4409.
doi: 10.1039/c8cc01568f.

Pd-catalyzed defluorination/arylation of α-trifluoromethyl ketones via consecutive β-F elimination and C-F bond activation

Lei Xu  1 , Qi Zhang, Qiang Xie, Bei Huang, Jian-Jun Dai, Jun Xu, Hua-Jian Xu
Affiliations

Pd-catalyzed defluorination/arylation of α-trifluoromethyl ketones via consecutive β-F elimination and C-F bond activation

Lei Xu et al. Chem Commun (Camb). .

Abstract

An unprecedented Pd-catalyzed activation of a CF3 group is reported herein. The key to the success of this reaction is the combination of consecutive β-F elimination and C-F bond oxidative addition of a trifluoromethyl group. It also represents the first general application of α-trifluoromethyl ketones as building blocks by C-F bond activation.

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