[Analysis of intrathecal immunity]
- PMID: 2964611
[Analysis of intrathecal immunity]
Abstract
The occurrence of an intrathecal immune reaction, specific to the central nervous system, may reflect either a contemporary systemic immune reaction or a local process directly related to the disease observed. Analysis of this reaction proceeds in 3 stages: the intrathecal production of immunoglobulins is assessed; the specific antibody activity of the intrathecal immunoglobulins is compared with that observed in serum; possible variations in components of complement are investigated. These different data are derived from the examination of serum and cerebrospinal fluid samples obtained simultaneously. The results of the analysis help in determining the cause of the disease, enable the severity and potential prognostic value of the immune reaction to be assessed and provide precise information on the influence of treatment on the course of the reaction. Several examples (syphilis, AIDS, measles panencephalitis, multiple sclerosis) illustrate these results.
Similar articles
-
Cerebrospinal fluid immunoglobulins and the central nervous system as an immunological organ particularly in multiple sclerosis and subacute sclerosing panencephalitis.Res Publ Assoc Res Nerv Ment Dis. 1971;49:112-55. Res Publ Assoc Res Nerv Ment Dis. 1971. PMID: 4107848 Review. No abstract available.
-
Intrathecal synthesis of proteins: from immunoglobulins to prealbumin.Ital J Neurol Sci. 1992 Dec;13(9 Suppl 14):69-77. Ital J Neurol Sci. 1992. PMID: 1345743
-
Quantitation of intrathecal antibodies in cerebrospinal fluid of subacute sclerosing panencephalitis, herpes simplex encephalitis and multiple sclerosis: discrimination between microorganism-driven and polyspecific immune response.J Neuroimmunol. 2007 Jul;187(1-2):139-46. doi: 10.1016/j.jneuroim.2007.04.002. Epub 2007 May 21. J Neuroimmunol. 2007. PMID: 17512988
-
[Oligoclonal and polyclonal gamma globulin bands in the cerebrospinal fluid in subacute sclerosing panencephalitis, multiple sclerosis and congenital infections of the central nervous system].Postepy Hig Med Dosw. 1987 Nov-Dec;41(6):663-72. Postepy Hig Med Dosw. 1987. PMID: 3330223 Review. Polish. No abstract available.
-
[Complement 3 level in the cerebrospinal fluid in multiple sclerosis].Neurol Neurochir Pol. 1980 May-Jun;14(3):275-82. Neurol Neurochir Pol. 1980. PMID: 7412984 Polish.