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. 2018 Apr 12;10(4):478.
doi: 10.3390/nu10040478.

Vitamin D Deficiency and Antenatal and Postpartum Depression: A Systematic Review

Fariba Aghajafari  1 , Nicole Letourneau  2 , Newsha Mahinpey  3 , Nela Cosic  4 , Gerald Giesbrecht  5
Affiliations

Vitamin D Deficiency and Antenatal and Postpartum Depression: A Systematic Review

Fariba Aghajafari et al. Nutrients. .

Abstract

Vitamin D has been implicated in antenatal depression (AD) and postpartum depression (PPD) in many studies; however, results have been inconsistent due to the complexity of this association. We searched the MEDLINE, Embase, PsycINFO, and Maternity and Infant Care databases for literature addressing associations between vitamin D and AD and PPD. Two independent authors reviewed titles and abstracts of the search results and selected studies for full review. Data were extracted, and a quality rating was done using the Newcastle-Ottawa Scale (NOS) on the selected studies. A total of 239 studies were identified; 14 were included in the review. The quality assessment of the included studies ranged from moderate to high. Of the studies on PPD, five of nine (55%) showed a significant association between vitamin D and PPD. Five of seven (71%) studies on AD showed a significant association with vitamin D status. As the included studies used different effect estimates and statistical analyses to report the association, it was not possible to transform the existing data into one single effect measure to employ meta-analytic techniques. While results of this systematic review vary, they indicate a significant association between vitamin D status and AD and PD.

Keywords: 25(OH)D; antenatal depression; depression; postnatal depression; pregnancy; vitamin D.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flowchart for selection of studies.
See this image and copyright information in PMC

References

    1. Dave S., Peterson I., Sherr L., Nazareth I. Incidence of maternal and paternal depression in primary care: A cohort study using a primary care database. Arch. Pediatr. Adolesc. Med. 2010;164:1038–1044. doi: 10.1001/archpediatrics.2010.184. - DOI - PubMed
    1. Wang J., Williams J., Lavorato D., Schmitz N., Dewa C., Patten S.B. The incidence of major depression in Canada: The National Population Health Survey. J. Affect. Disord. 2010;123:158–163. doi: 10.1016/j.jad.2009.07.016. - DOI - PubMed
    1. Gavin N.I., Gaynes B.N., Lohr K.N., Meltzer-Brody S., Gartlehner G., Swinson T. Perinatal depression: A systematic review of prevalence and incidence. Obstet. Gynecol. 2005;106:1071–1083. doi: 10.1097/01.AOG.0000183597.31630.db. - DOI - PubMed
    1. O’Hara M.W., Wisner K.L. Perinatal mental illness: Definition, description and aetiology. Best. Pract. Res. Clin. Obstet. Gynaecol. 2014;28:3–12. doi: 10.1016/j.bpobgyn.2013.09.002. - DOI - PMC - PubMed
    1. Letourneau N.L., Dennis C.-L., Linder J., Cosic N. The effect of perinatal depression treatment for mothers on parenting and child development: A systematic review. Depress. Anxiety. 2017;34:928–966. doi: 10.1002/da.22687. - DOI - PubMed

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