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Comment
. 2018 Jun;28(6):417-419.
doi: 10.1016/j.tcb.2018.03.005. Epub 2018 Apr 10.

Asymmetric Tyrosination of Spindle Microtubules Facilitates Selfish Inheritance

Shikha Laloraya  1
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Comment

Asymmetric Tyrosination of Spindle Microtubules Facilitates Selfish Inheritance

Shikha Laloraya. Trends Cell Biol. 2018 Jun.

Abstract

Meiotic drive is an enigmatic process that results from biased segregation of selfish genetic elements that enhance their own transmission and drive evolution. During asymmetric female meiotic divisions, selfish elements segregate preferentially towards the egg rather than polar bodies. Recent findings demonstrate that asymmetric spindle tyrosination helps selfish elements to cheat.

Keywords: CENP-A; Cdc42; TTL; centromere; meiotic drive; microtubule tyrosination; selfish genetic element; spindle asymmetry.

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