Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2018 Apr 12;131(15):1633-1635.
doi: 10.1182/blood-2018-02-829069.

Can genetics resolve what Notch does in HSCs?

Ivan Maillard  1 , Warren S Pear  1
Affiliations
Comment

Can genetics resolve what Notch does in HSCs?

Ivan Maillard et al. Blood. .

Abstract

The effects of Notch signaling in hematopoietic stem and progenitor cells remain controversial. In work presented in this issue of Blood, Duarte et al interfere genetically with the Notch transcriptional complex (NTC) in hematopoiesis and demonstrate that canonical Notch signals are dispensable in primitive hematopoietic progenitors, as well as across the myeloid, erythroid (E), and megakaryocyte (Mk) lineages.

PubMed Disclaimer

Conflict of interest statement

Conflict-of-interest disclosure: The authors declare no competing financial interests.

Comment on

References

    1. Duarte S, Woll PS, Buza-Vidas N, et al. Canonical Notch signaling is dispensable for adult steady-state and stress myelo-erythropoiesis. Blood. 2018;131(15):1712-1719. - PMC - PubMed
    1. Oh P, Lobry C, Gao J, et al. . In vivo mapping of notch pathway activity in normal and stress hematopoiesis [published correction appears in Cell Stem Cell. 2013;13(2):256]. Cell Stem Cell. 2013;13(2):190-204. - PMC - PubMed
    1. Maillard I, Koch U, Dumortier A, et al. . Canonical notch signaling is dispensable for the maintenance of adult hematopoietic stem cells. Cell Stem Cell. 2008;2(4):356-366. - PMC - PubMed
    1. Benveniste P, Serra P, Dervovic D, et al. . Notch signals are required for in vitro but not in vivo maintenance of human hematopoietic stem cells and delay the appearance of multipotent progenitors. Blood. 2014;123(8):1167-1177. - PubMed
    1. Mercher T, Cornejo MG, Sears C, et al. . Notch signaling specifies megakaryocyte development from hematopoietic stem cells. Cell Stem Cell. 2008;3(3):314-326. - PMC - PubMed

Publication types

Substances