Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Jan;7(1):34-44.

Comparison of Albizia Julibressin and Silver Sulfadiazine in Healing of Second and Third Degree Burns

Hossein Asgarirad  1 , Aroona Chabra  2   3 , Mahnaz Rahimnejad  2 , Ahmad Zaghi Hosseinzadeh  4 , Ali Davoodi  3 , Mohammad Azadbakht  3
Affiliations

Comparison of Albizia Julibressin and Silver Sulfadiazine in Healing of Second and Third Degree Burns

Hossein Asgarirad et al. World J Plast Surg. 2018 Jan.

Abstract

Background: Large numbers of population suffer from burn annually. The promising treatment of burn has not been identified yet. Albizia julibressin (A. julibressin) in Fabaceae family is popular for its antiseptic activity. This prospective study was designed to compare the wound healing effects of A. julibressin gel (AG) with silver sulfadiazine (SSD).

Methods: This single blind clinical trial was performed on 40 patients with second and third degree burns. 20 patients treated with SSD and 20 other patients received A. julibressin. The percentage of the wound healing was evaluated with pain, irritation, edema, itching, erythema, purulent discharges and skin discoloration symptoms. Also, the patients' satisfaction and adverse drug reactions were determined.

Results: The severity of pain (p=0.03), inflammation (p=0.02) and purulent secretions (p=0.03) were significantly relieved in A. julibressin group. The healing time significantly reduced in second degree burns (p=0.03) and third degree burns (p=0.04) with treating by A. julibressin. No significant adverse drug reactions were detected with A. julibressin.

Conclusion: It seems that A. julibressin improves the different therapeutic aspects of burn injuries and could be considered as a new herbal remedy in wound healings.

Keywords: Albizia julibressin; Burns; Healing; Herbal Medicine; Wound.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
A. julibressin tree in Hizarjarib forest, near Neka city, Mazandaran Province, Iran.
Fig. 2
Fig. 2
Standard curve of the total amount of triterpenoids saponins based on Aecsine.
Fig. 3
Fig. 3
Comparison of relieving pain in A. julibrissin (AG) and silver sulfadiazine (SSD) groups (1: first of the admission, 2: The middle day of treatment period, 3: The last day of treatment).
Fig. 4
Fig. 4
Comparison of relieving inflammation in A. julibrissin (AG) and silver sulfadiazine (SSD) groups (1: first of the admission, 2: The middle day of treatment period, 3: The last day of treatment).
Fig. 5
Fig. 5
Comparison of relieving purulent discharge in A. julibrissin (AG) and silver sulfadiazine (SSD) groups (1: first of the admission, 2: The middle day of treatment period, 3: The last day of treatment).
Fig. 6
Fig. 6
Comparison of the wound healing progress in third degree burns between two groups after 14 days of treatment (left: silver sulfadiazine, right: A. julibrissin).
Fig. 7
Fig. 7
Comparison of the wound healing progress in second degree burns between two groups after 14 days of treatment (left: silver sulfadiazine, right: A. julibrissin).
See this image and copyright information in PMC

References

    1. Akhoondinasab MR, Khodarahmi A, Akhoondinasab M, Saberi M, Iranpour M. Assessing effect of three herbal medicines in second and third degree burns in rats and comparison with silver sulfadiazine ointment. Burns. 2015;41:125–31. - PubMed
    1. Espiritu AA, Lao SNL, Guerrero JJG. Burn wound healing potential of Bixa orellana Linn [Bixaceae] leaf extracts on albino mice. J Med Plants. 2016;4:84–7.
    1. Patila S, Desaia N, Mahadika K, Paradkar A. Can green synthesized propolis loaded silver nanoparticulate gel enhance wound healing caused by burns? Euro J Integ Med. 2015;7:243–50.
    1. Jani M. Role of Homoeopathy in the treatment of cases of heartburn with the help of different repertory and Materia Medica Pura. Euro J Integ Med. 2009;1:233–4.
    1. Cuttle L1, Kempf M, Kravchuk O, George N, Liu PY, Chang HE, Mill J, Wang XQ, Kimble RM. The efficacy of Aloe vera, tea tree oil and saliva as first aid treatment for partial thickness burn injuries. Burns. 2008;34:1176–82. - PubMed

LinkOut - more resources