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. 2018 Jan 30:2018:4340871.
doi: 10.1155/2018/4340871. eCollection 2018.

Oxidative Stress Markers Patients with Parotid Gland Tumors: A Pilot Study

Pawel Sowa  1 , Maciej Misiolek  1 , Bartlomiej Pasinski  2 , Grzegorz Bartosz  2 , Miroslaw Soszynski  2 , Monika Adamczyk-Sowa  3 , Izabela Sadowska-Bartosz  4
Affiliations

Oxidative Stress Markers Patients with Parotid Gland Tumors: A Pilot Study

Pawel Sowa et al. Biomed Res Int. .

Abstract

Salivary gland tumors account for 3-6% of tumors of the head and neck. About 80% of salivary gland tumors occur in parotid glands. Oxidative stress (OS) is implicated in the origin, development, and whole-body effects of various tumors. There are no data on the occurrence of OS in the parotid gland tumors. The aim of this study was to ascertain if whole-body OS accompanies parotid gland tumors, based first of all on oxidative modifications of blood serum proteins and other markers of OS in the serum of the patients. The group studied included 17 patients with pleomorphic adenoma, 9 patients with Warthin's tumor, 8 patients with acinic cell carcinoma, and 24 age-matched controls. We found increased concentration of interleukin 4 in patients with acinic cell carcinoma, decreased plasma thiols, increased AOPP concentration, and decreased FRAP of blood serum in all groups of the patients while protein oxidative modifications assessed fluorimetrically, protein carbonyls, protein nitration, malondialdehyde concentration, and serum ABTS⁎-scavenging capacity were unchanged. These data indicate the occurrence of OS in patients with parotid gland tumors and point to various sensitivities of OS markers.

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Figures

Figure 1
Figure 1
Pleomorphic adenoma of parotid gland: the intraoperative view after removing of the tumor (Tumor) together with a part of superior lobe of parotid glad (Parotid).
Figure 2
Figure 2
Surgical view of the left facial nerve (n. VII) after removal of the tumor and superficial lobe of the parotid gland. The main trunk (Trunk) of the nerve and its main branches: temporal (Temp.), zygomatic (Zyg.), buccal (Bucc.), and mandibular (Mand.) were marked by arrows. Cartilage of external auditory canal was marked as EAC and retromandibular vein as RMV.
Figure 3
Figure 3
Serum IL-4 concentration in patients with parotid gland tumors; ∗P < 0.05.
Figure 4
Figure 4
Serum thiol group content in patients with parotid gland tumors; ∗P < 0.05.
Figure 5
Figure 5
Serum AOPP concentration in patients with parotid gland tumors; ∗P < 0.05.
Figure 6
Figure 6
Serum FRAP in patients with parotid gland tumors; ∗P < 0.05.
See this image and copyright information in PMC

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