Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2018 May-Jun;24(3):141-150.
doi: 10.4103/sjg.SJG_603_17.

Prevalence of sleep disorder in irritable bowel syndrome: A systematic review with meta-analysis

Ben Wang  1 , Ruqiao Duan  1 , Liping Duan  1
Affiliations
Meta-Analysis

Prevalence of sleep disorder in irritable bowel syndrome: A systematic review with meta-analysis

Ben Wang et al. Saudi J Gastroenterol. 2018 May-Jun.

Abstract

Background/aims: We conducted this meta-analysis to evaluate the prevalence of sleep disorder in irritable bowel syndrome (IBS) patients and study the association between IBS and sleep disorder.

Materials and methods: A systematic search was conducted by searching PubMed, Embase, and Cochrane library databases using the following search terms: "functional gastrointestinal disorders," "Sleep disturbance," "Sleep disorder," "insomnia," "Dysomnias," "irritable bowel syndrome," and "IBS." Studies evaluating the association between IBS and sleep disorder were identified. Data analysis was conducted using meta-analysis software Comprehensive Meta-Analysis (CMA) 2.0. Heterogeneity across studies was evaluated by χ2and I2statistics. Publication bias was evaluated by funnel plot, Begg's test, and Egger's test. Sensitivity analysis was also performed by removing each single study separately.

Results: The bibliographical search yielded a total of 2866 studies. Finally, 36 studies including 63620 participants were identified. The prevalence of sleep disorder in IBS was 37.6% (95% CI: 31.4% to 44.3%) based on this meta-analysis. The pooled odds ratio was 2.618 (95% CI: 2.052% to 3.341). Publication bias was not determined. Regarding the sensitivity analysis, the outcome was stable regardless of which study was removed.

Conclusions: The prevalence of sleep disorder was higher in IBS compared to healthy controls and may be associated with the pathogenesis of IBS. The prevalence of sleep disorder in IBS may differ according to different areas, age, gender, occupation, and IBS diagnostic criteria. Further studies are needed to investigate any possible causal relationship between sleep disorder and IBS.

Keywords: Irritable bowel syndrome; meta-analysis; prevalence; sleep disorder.

PubMed Disclaimer

Conflict of interest statement

There are no conflicts of interest

Figures

Figure 1
Figure 1
Flow diagram for the selection of studies
Figure 2
Figure 2
The pooled prevalence of sleep disorders among IBS
Figure 3
Figure 3
The summary odds ratio of sleep disorders among IBS
Figure 4
Figure 4
Sensitivity analysis
Figure 5
Figure 5
Funnel plot
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Cao X, Wang S, Zhong B, Zhang L, Ungvari GS, Ng CH, et al. The prevalence of insomnia in the general population in China: A meta-analysis. Plos One. 2017;12:e0170772. - PMC - PubMed
    1. Colten HR, Bruce M. Sleep Disorders and Sleep Deprivation: An Unmet Public Health Problem. Washington (DC): National Academies Press (US); 2006. - PubMed
    1. Kushida CA, Chang A, Gadkary C, Guilleminault C, Carrillo O, Dement WC. Comparison of actigraphic, polysomnographic, and subjective assessment of sleep parameters in sleep-disordered patients. Sleep Med. 2001;2:389–96. - PubMed
    1. Zhang B, Wing YK. Sex differences in insomnia: A meta-analysis. Sleep. 2006;29:85–93. - PubMed
    1. Luyster FS, Strollo PJ, Zee PC, Walsh JK. Sleep: A Health Imperative. Sleep. 2012;35:727–34. - PMC - PubMed