Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Feb;21(2):156-164.
doi: 10.1177/1098612X18764591. Epub 2018 Apr 13.

Age-based ultrasonographic criteria for diagnosis of autosomal dominant polycystic kidney disease in Persian cats

Juliana M Guerra  1   2 , Mariana F Freitas  3 , Alexandre Gt Daniel  4 , Arine Pellegrino  3   4 , Natália C Cardoso  1 , Isac de Castro  5 , Luiz F Onuchic  5 , Bruno Cogliati  1
Affiliations

Age-based ultrasonographic criteria for diagnosis of autosomal dominant polycystic kidney disease in Persian cats

Juliana M Guerra et al. J Feline Med Surg. 2019 Feb.

Abstract

Objectives: The aim of this study was to establish ultrasound criteria for the diagnosis of autosomal dominant polycystic kidney disease (ADPKD) in Persian cats.

Methods: Eighty-two Persian cats were assessed using renal ultrasound and genotyped for the C→A transversion in exon 29 of PKD1. The animals were also submitted to hematological characterization, serum biochemistry analyses and urinalysis.

Results: Age, sex and neutering status did not differ between ADPKD (n = 12) and non-ADPKD (n = 70) cats. After integrated molecular genetics/ultrasonographic analysis, the presence of at least one renal cyst was sufficient to establish a diagnosis of ADPKD in animals up to 15 months of age. Two or more cysts were required for diagnosis in cats aged 16-32 months, and at least three cysts warranted diagnosis of ADPKD in animals aged 33-49 months. Finally, four or more cysts led to diagnosis in cats aged 50-66 months. Although cats with ADPKD exhibited higher serum calcium levels than non-affected cats, hematological, urinalysis and other biochemical parameters did not differ between the two groups.

Conclusions and relevance: Integrated analyses of imaging and molecular genetics data enabled, for the first time, the establishment of age-based ultrasonographic criteria for the diagnosis of ADPKD in Persian cats. The development of imaging criteria is particularly relevant and useful in the clinical setting given the current limitations to access and the cost of molecular genetics-based diagnostic tests.

PubMed Disclaimer

Conflict of interest statement

The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1
Figure 1
(a) Receiver–operating characteristic (ROC) curves for age and number of cysts detected in Persian cats with autosomal dominant polycystic kidney disease (ADPKD). The area under the ROC curve for age was 0.636 (95% confidence interval [CI] 0.437–0.835; P <0.05) and 1 for number of cysts (95% CI 100–100%; P <0.05) for ADPKD diagnosis. (b) Linear regression curve trend line for age and number of cysts detected in Persian cats with ADPKD
See this image and copyright information in PMC

References

    1. Spithoven E, Kramer A, Meijer E, et al. . Renal replacement therapy for autosomal dominant polycystic kidney disease (ADPKD) in Europe: prevalence and survival – an analysis of data from the ERA-EDTA Registry. Nephrol Dial Transplant 2014; 29: 15–25. - PMC - PubMed
    1. Torres VE, Harris PC, Pirson Y. Autosomal dominant polycystic kidney disease. Lancet 2007; 369: 1287–1301. - PubMed
    1. Chapman AB, Devuyst O, Eckardt KU, et al. . Autosomal-dominant polycystic kidney disease (ADPKD): executive summary from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies conference. Kidney Int 2015; 88: 17–27. - PMC - PubMed
    1. Harris PC, Torres VE. Polycystic kidney disease, autosomal dominant. In: Pagon RA, Adam MP, Ardinger HH, et al. (eds). GeneReviews [Internet]. Seattle, WA: University of Washington, Seattle, 1993–2017. https://www.ncbi.nlm.nih.gov/books/NBK1246/ (updated June 11, 2015). - PubMed
    1. Ravine D, Gibson RN, Walker RG, et al. . Evaluation of ultrasonographic diagnostic criteria for autosomal dominant polycystic kidney disease 1. Lancet 1994; 343: 824–827. - PubMed

Publication types

LinkOut - more resources