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Review
. 2018:155:69-83.
doi: 10.1016/bs.pmbts.2017.12.002. Epub 2018 Feb 1.

Dwarf Mice and Aging

Michal M Masternak  1 , Justin Darcy  2 , Berta Victoria  3 , Andrzej Bartke  4
Affiliations
Review

Dwarf Mice and Aging

Michal M Masternak et al. Prog Mol Biol Transl Sci. 2018.

Abstract

Dwarf mice have been studied for many decades, however, the focus of these studies shifted in 1996 when it was shown by Brown-Borg and her coworkers that Ames dwarf (Prop1df) mice are exceptionally long-lived. Since then, Snell dwarf (Pit1dw) and growth hormone receptor knockout (GHR-KO, a.k.a. Laron dwarf) mice were also shown to be exceptionally long-lived, presumably due to their growth hormone (GH)-deficiency or -resistance, respectively. What is of equal importance in these dwarf mice is their extended health span, that is, these animals have a longer period of life lived free of frailty and age-related diseases. This review article focuses on recent studies conducted in these dwarf mice, which concerned brown and white adipose tissue biology, microRNA (miRNA) profiling, as well as early-life dietary and hormonal interventions. Results of these studies identify novel mechanisms linking reduced GH action with extensions of both life span and health span.

Keywords: Ames dwarf; GHR-KO; aging; dwarf; growth hormone.

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