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Comment
. 2018 Apr 15;78(8):1904-1905.
doi: 10.1158/0008-5472.CAN-17-3590.

The Plausibility of the Obesity Paradox in Cancer-Response-Reply to Point

Elizabeth M Cespedes Feliciano  1 , Candyce H Kroenke  1 , Bette J Caan  2
Affiliations
Comment

The Plausibility of the Obesity Paradox in Cancer-Response-Reply to Point

Elizabeth M Cespedes Feliciano et al. Cancer Res. .
No abstract available

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Body Mass Index, Visceral Adiposity Index, and Overall Mortality Following Non-Metastatic Breast Cancer: Results by Race from the B-SCANS Study at Kaiser Permanente Northern California and the Dana Farber Cancer Institute This figure was adapted from the following presentation at the American Association of Cancer Research (AACR): Cespedes Feliciano, EM. Multiethnic differences in BMI, body composition, and survival in colorectal and breast cancer. Tenth AACR Conference on The Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved, Atlanta, GA. September 28, 2017 For analyses of body mass index (BMI), the reference category is set to the midpoint of the “normal-weight” BMI category, 22.5-kg/m2. Models adjust for age, tumor stage, hormone receptor and HER2 status, receipt of chemotherapy and/or radiation, smoking and alcohol intake, and Charlson score. Visceral adiposity index is the centimeters squared of visceral fat at the third lumbar vertebra from a CT scan taken within 3 months of breast cancer diagnosis, scaled to height in meters squared. For analyses of visceral adiposity index, the reference category is set to group midpoint: 30 cm2/m2. Models adjust for the covariates above as well as skeletal muscle index, subcutaneous fat index, and the residuals of BMI
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References

    1. Kroenke CH, Neugebauer R, Meyerhardt J, et al. Analysis of Body Mass Index and Mortality in Patients With Colorectal Cancer Using Causal Diagrams. JAMA oncology. 2016;2(9):1137–1145. - PMC - PubMed
    1. Cespedes Feliciano EM. Multiethnic differences in BMI, body composition, and survival in colorectal and breast cancer; Presentation at the Tenth AACR Conference on The Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved: American Association for Cancer Research; September 25–27, 2017.
    1. Caan BJ, Meyerhardt JA, Kroenke CH, et al. Explaining the Obesity Paradox: The Association between Body Composition and Colorectal Cancer Survival (C-SCANS Study) Cancer Epidemiology Biomarkers & Prevention. 2017;26(7):1008–1015. - PMC - PubMed

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