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Review
. 2018 Nov:196:59-63.
doi: 10.1016/j.clim.2018.04.002. Epub 2018 Apr 11.

Immune senescence, epigenetics and autoimmunity

Affiliations
Review

Immune senescence, epigenetics and autoimmunity

Donna Ray et al. Clin Immunol. 2018 Nov.

Abstract

Aging of the immune system in humans and animals is characterized by a decline in both adaptive and innate immune responses. Paradoxically, aging is also associated with a state of chronic inflammation ("inflammaging") and an increased likelihood of developing autoimmune diseases. Epigenetic changes in non-dividing and dividing cells, including immune cells, due to environmental factors contribute to the inflammation and autoimmunity that characterize both the state and diseases of aging. Here, we review the epigenetic mechanisms involved in the development of immune senescence and autoimmunity in old age.

Keywords: Autoimmunity; Epigenetics; Immune senescence; Inflammation.

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References

    1. Aho K, Koskenvuo M, Tuominen J, Kaprio J, Occurrence of rheumatoid arthritis in a nationwide series of twins, J Rheumatol, 13 (1986) 899–902. - PubMed
    1. Krueger GG, Duvic M, Epidemiology of psoriasis: clinical issues, The Journal of investigative dermatology, 102 (1994) 14S–18S. - PubMed
    1. Ballestar E, Epigenetics lessons from twins: prospects for autoimmune disease, Clinical reviews in allergy & immunology, 39 (2010) 30–41. - PubMed
    1. Meda F, Folci M, Baccarelli A, Selmi C, The epigenetics of autoimmunity, Cellular & molecular immunology, 8 (2011) 226–236. - PMC - PubMed
    1. Fraga MF, Ballestar E, Paz MF, Ropero S, Setien F, Ballestar ML, Heine-Suner D, Cigudosa JC, Urioste M, Benitez J, Boix-Chornet M, Sanchez-Aguilera A, Ling C, Carlsson E, Poulsen P, Vaag A, Stephan Z, Spector TD, Wu YZ, Plass C, Esteller M, Epigenetic differences arise during the lifetime of monozygotic twins, Proc Natl Acad Sci U S A, 102 (2005) 10604–10609. - PMC - PubMed

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