Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 May;36(2):253-260.
doi: 10.1016/j.ncl.2018.01.002.

Generalized Myasthenia Gravis: Classification, Clinical Presentation, Natural History, and Epidemiology

Michael K Hehir  1 , Nicholas J Silvestri  2
Affiliations
Review

Generalized Myasthenia Gravis: Classification, Clinical Presentation, Natural History, and Epidemiology

Michael K Hehir et al. Neurol Clin. 2018 May.

Abstract

Myasthenia gravis (MG) is a rare disease, but the most common disorder of the neuromuscular junction. It is the prototypic autoimmune disease most commonly caused by antibodies to the acetylcholine receptor (AChR) leading to characteristic fatigable weakness of the ocular, bulbar, respiratory, axial, and limb muscles. The majority of patients with MG first present with ocular symptoms. Most patients with MG will experience at least 1 exacerbation of symptoms throughout the course of their illness. This article will cover the epidemiology, clinical presentation, classification, and natural history of MG.

Keywords: Acetylcholine receptor; Antimuscle-specific kinase; Myasthenia gravis; Occular.

PubMed Disclaimer

MeSH terms